Shopping Cart

Your shopping cart is currently empty

Bis-ANS dipotassium

Name: Bis-ANS dipotassium
Brand: TargetMol
SKU: T36956
Price: 152 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: bis-ANS (potassium salt), 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid) Copy Product Info

🥰Excellent

Synonyms: bis-ANS (potassium salt), 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid

Catalog No. T36956 Copy Product Info

🥰Excellent

Bis-ANS dipotassium, as a type of protein fluorescent probe, can specifically bind to tubulin with a dissociation constant (Kd) of 2 μM [1]. Meanwhile, Bis-ANS dipotassium is also an efficient biphasic regulator of protein liquid-liquid phase separation (LLPS), exerting a significant concentration-dependent regulatory effect: it promotes liquid-liquid phase separation at low concentrations while exerting an inhibitory effect at high concentrations [2].

Cas No. 65664-81-5

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$152	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:Yellow

Resource Download

COA

Product Introduction

Bioactivity

Description	Bis-ANS dipotassium, as a type of protein fluorescent probe, can specifically bind to tubulin with a dissociation constant (Kd) of 2 μM [1]. Meanwhile, Bis-ANS dipotassium is also an efficient biphasic regulator of protein liquid-liquid phase separation (LLPS), exerting a significant concentration-dependent regulatory effect: it promotes liquid-liquid phase separation at low concentrations while exerting an inhibitory effect at high concentrations [2].
In vitro	Methods: Protein-related detection and regulation experiments were performed using the Bis-ANS dipotassium fluorescent molecule. Results: Bis-ANS dipotassium is a divalent naphthalenesulfonate fluorescent molecule with an anilino group. It can be used to detect exposed hydrophobic patches on proteins, monitor the formation of protein aggregates, and modulate liquid–liquid phase separation of the low-complexity domain (LCD) of TDP-43 [2]. Methods: L. cuprina was treated with Argifin. Results: Argifin exhibited an inhibitory effect on molting in L. cuprina [1].
Synonyms	bis-ANS (potassium salt), 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid

Chemical Properties

Molecular Weight	672.85
Formula	C₃₂H₂₂K₂N₂O₆S₂
Cas No.	65664-81-5
Smiles	[K].[K].OS(=O)(=O)c1cccc2c(ccc(Nc3ccccc3)c12)-c1ccc(Nc2ccccc2)c2c(cccc12)S(O)(=O)=O

Storage & Solubility Information

Storage

Keep away from moistureKeep away from direct sunlight Store at -20°C Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 24 mg/mL (35.67 mM), Sonication is recommended.

DMF: 30 mg/mL (44.59 mM), Sonication is recommended.

Ethanol: Slightly Soluble

Solution Preparation Table

DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	1.4862 mL	7.4311 mL	14.8622 mL	74.3108 mL
5 mM	0.2972 mL	1.4862 mL	2.9724 mL	14.8622 mL
10 mM	0.1486 mL	0.7431 mL	1.4862 mL	7.4311 mL
20 mM	0.0743 mL	0.3716 mL	0.7431 mL	3.7155 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

Bis-ANS dipotassiumBisANS dipotassiumBis-ANSBis ANS dipotassium

Related Tags: Bis-ANS dipotassium chemical structure | Bis-ANS dipotassium in vitro | Bis-ANS dipotassium formula | Bis-ANS dipotassium molecular weight