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ABT-046

Name: ABT-046
Brand: TargetMol
SKU: T14085
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14085Cas No. 1031336-60-3

Alias ABT046

ABT-046 is an orally active, selective, and highly efficient Diacylglycerol Acyltransferase 1 (DGAT-1) inhibitor that can be used in metabolic disease research.

ABT-046

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Purity: 98.13%

Catalog No. T14085Alias ABT046Cas No. 1031336-60-3

ABT-046 is an orally active, selective, and highly efficient Diacylglycerol Acyltransferase 1 (DGAT-1) inhibitor that can be used in metabolic disease research.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.13%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	ABT-046 is an orally active, selective, and highly efficient Diacylglycerol Acyltransferase 1 (DGAT-1) inhibitor that can be used in metabolic disease research.
Targets&IC50	DGAT-1 (human):78 nM
In vitro	ABT-046 did not significantly inhibit human DGAT-2, but prevented human DGAT-1 from catalyzing triglyceride production in HeLa cells, with an IC50 of 78 nM.[1] In Caco-2 cells, ABT-046 exhibited high in vitro permeability and no active efflux was detected (efflux ratios of 1.4 and 1.1 at 0.5 and 5 μM, respectively).[1] ABT-046 was also found to inhibit human DGAT-2, but prevented human DGAT-1 from catalyzing triglyceride production in HeLa cells with an IC50 of 78 nM. [1] The metabolic conversion of ABT-046 to mouse and human liver microsomes is extremely low and almost negligible. [1]
In vivo	Single gavage administration of ABT-046 (0.03-3 mg/kg) significantly reduced postprandial triglyceride levels in CD-1 mice. [1] Single gavage administration of ABT-046 (0.3 mg/kg) effectively suppressed postprandial triglyceride fluctuations in diet-induced obese mice. [1]
Synonyms	ABT046

Chemical Properties

Molecular Weight	350.41
Formula	C₂₀H₂₂N₄O₂
Cas No.	1031336-60-3
Smiles	NC1=C(C=NC=2N1N=CC2)C3=CC=C(C=C3)[C@@H]4CC[C@@H](CC(O)=O)CC4
Relative Density.	1.39 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (142.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8538 mL	14.2690 mL	28.5380 mL	142.6900 mL
5 mM	0.5708 mL	2.8538 mL	5.7076 mL	28.5380 mL
10 mM	0.2854 mL	1.4269 mL	2.8538 mL	14.2690 mL
20 mM	0.1427 mL	0.7134 mL	1.4269 mL	7.1345 mL
50 mM	0.0571 mL	0.2854 mL	0.5708 mL	2.8538 mL
100 mM	0.0285 mL	0.1427 mL	0.2854 mL	1.4269 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc