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Phanginin A

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Catalog No. T73074Cas No. 1011528-58-7

Phanginin A, a natural product discovered in Caesalpinia sappan Linn, activates SIK1 and inhibits gluconeogenesis in mouse primary hepatocytes. Phanginin A increases PDE4 activity and suppresses the hepatic cAMP/PKA/CREB pathway, improving metabolic disorders in ob/ob mice. It may be used in studies of type 2 diabetes.

Phanginin A

Phanginin A

😃Good
Purity: 95.54%
Catalog No. T73074Cas No. 1011528-58-7
Phanginin A, a natural product discovered in Caesalpinia sappan Linn, activates SIK1 and inhibits gluconeogenesis in mouse primary hepatocytes. Phanginin A increases PDE4 activity and suppresses the hepatic cAMP/PKA/CREB pathway, improving metabolic disorders in ob/ob mice. It may be used in studies of type 2 diabetes.
Pack SizePriceAvailabilityQuantity
5 mg$1,400In Stock
10 mg$1,830In Stock
50 mg$3,1107-10 days
100 mg$4,9707-10 days
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:95.54%
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Product Introduction

Bioactivity
Description
Phanginin A, a natural product discovered in Caesalpinia sappan Linn, activates SIK1 and inhibits gluconeogenesis in mouse primary hepatocytes. Phanginin A increases PDE4 activity and suppresses the hepatic cAMP/PKA/CREB pathway, improving metabolic disorders in ob/ob mice. It may be used in studies of type 2 diabetes.
In vitro
In primary mouse hepatocytes, Phanginin A (5, 10 µM, 0-120 minutes) inhibited p-CREB expression in a time- and dose-dependent manner, while Phanginin A (2.5, 5, 10 µM, 0-120 minutes) promoted p-SIK1 expression in a time- and dose-dependent fashion [1].
In vivo
In the type 2 diabetes ob/ob mouse model, a single oral administration of Phanginin A (100 mg/kg) demonstrated anti-Vitis vinifera ketone effects [1]. Continuous once-daily oral administration of Phanginin A (100 mg/kg) for 26 days effectively improved metabolic parameters in ob/ob mice [1].
Chemical Properties
Molecular Weight360.44
FormulaC21H28O5
Cas No.1011528-58-7
SmilesO[C@H]1[C@@]23[C@]([C@@](C(OC)=O)(CO1)CCC2)(CC[C@@]4([C@@]3(CC5=C([C@@H]4C)C=CO5)[H])[H])[H]
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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