Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-Posenacaftor ((R)-PTI-801) sodium, the R enantiomer of Posenacaftor, is a cystic fibrosis transmembrane regulator (CFTR) protein modulator. It corrects the folding and trafficking of the CFTR protein, and is utilized in the research of cystic fibrosis (CF)[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,220.00 | |
50 mg | 6-8 weeks | $ 1,590.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | (R)-Posenacaftor ((R)-PTI-801) sodium, the R enantiomer of Posenacaftor, is a cystic fibrosis transmembrane regulator (CFTR) protein modulator. It corrects the folding and trafficking of the CFTR protein, and is utilized in the research of cystic fibrosis (CF)[1]. |
In vitro | Cystic fibrosis (CF) is an autosomal recessive disorder resulting from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene[1]. These mutations cause the CFTR protein, a cAMP-regulated chloride channel primarily found on the epithelial cells' apical membrane, to be defective and misfolded, disrupting ion flow across cell membranes[1]. Posenacaftor acts as a CFTR corrector, designed to repair and restore the defective CFTR protein's function. Once corrected, the CFTR protein is transported to the cell surface, where it resumes its role as a chloride channel, aiding in the regulation of fluid balance in the airways[2]. |
Molecular Weight | 468.505 |
Formula | C27H27NNaO5 |
CAS No. | 2095064-09-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 38.33 mg/mL (81.99 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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(R)-Posenacaftor sodium 2095064-09-6 (R)Posenacaftor sodium Posenacaftor sodium (R) Posenacaftor sodium inhibitor inhibit