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Tebotelimab
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Catalog No. T76985Cas No. 2245725-04-4
Tebotelimab (MGD-013) is a bispecific antibody targeting PD-1 and LAG-3, classified as a human IgG4κ dual-affinity re-targeting (DART) molecule. It has binding affinities with EC50 values of 1.65 nM for PD-1 and 0.41 nM for LAG-3 on NS0 cells. The compound inhibits PD-1/PD-L1, PD-1/PD-L2, and LAG-3/HLA (MHC-II) interactions, as well as PD-1 signaling pathways, thereby reinvigorating exhausted T-cell responses and bolstering antitumor immunity [1] [2] [3].
Tebotelimab
Tebotelimab
Copy Product Info😃Good
Catalog No. T76985Cas No. 2245725-04-4
Tebotelimab (MGD-013) is a bispecific antibody targeting PD-1 and LAG-3, classified as a human IgG4κ dual-affinity re-targeting (DART) molecule. It has binding affinities with EC50 values of 1.65 nM for PD-1 and 0.41 nM for LAG-3 on NS0 cells. The compound inhibits PD-1/PD-L1, PD-1/PD-L2, and LAG-3/HLA (MHC-II) interactions, as well as PD-1 signaling pathways, thereby reinvigorating exhausted T-cell responses and bolstering antitumor immunity [1] [2] [3].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $539 | 2-4 weeks | 2-4 weeks | |
| 5 mg | $1,390 | 2-4 weeks | 2-4 weeks | |
| 10 mg | $2,220 | 2-4 weeks | 2-4 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Tebotelimab (MGD-013) is a bispecific antibody targeting PD-1 and LAG-3, classified as a human IgG4κ dual-affinity re-targeting (DART) molecule. It has binding affinities with EC50 values of 1.65 nM for PD-1 and 0.41 nM for LAG-3 on NS0 cells. The compound inhibits PD-1/PD-L1, PD-1/PD-L2, and LAG-3/HLA (MHC-II) interactions, as well as PD-1 signaling pathways, thereby reinvigorating exhausted T-cell responses and bolstering antitumor immunity [1] [2] [3]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Target | PD-1/LAG-3 |
| Cas No. | 2245725-04-4 |
| Storage | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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