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TGF beta 3 Protein, Human/Mouse/Rat, Recombinant

Catalog No. TMPJ-00254
Synonyms: Latency-associated peptide, TGF-beta-3, Transforming growth factor beta-3, TGFB3, TGF-β-3, LAP, Transforming growth factor β-3

Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
Pack Size Availability Price/USD Quantity
10 μg In stock $ 118.00
50 μg 5 days $ 350.00
500 μg 5 days $ 1,520.00
1 mg 5 days $ 3,790.00
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Biological Description
Technical Params
Product Properties
Biological Information Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells. The ED50 for this effect is 10-80 pg/ml. (QC verified)

Description Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.
Species Human,Mouse,Rat
Expression System Human Cells
Tag None
Accession Number P10600
Synonyms Latency-associated peptide, TGF-beta-3, Transforming growth factor beta-3, TGFB3, TGF-β-3, LAP, Transforming growth factor β-3
Amino Acid Ala301-Ser412(Tyr340Phe)
Construction Recombinant Human/Mouse/Rat Transforming Growth Factor Beta 3 is produced by our Mammalian expression system and the target gene encoding Ala301-Ser412(Tyr340Phe) is expressed.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

Molecular Weight 12-14 KDa, reducing conditions
Endotoxin Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH 2.5.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.

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Keywords

TGF beta 3 Protein, Human/Mouse/Rat, Recombinant Latency-associated peptide Transforming growth factor b-3 TGF-beta-3 Transforming growth factor beta-3 TGFB 3 TGFB3 TGF-β-3 LAP TGFB-3 TGF-b-3 Transforming growth factor β-3 recombinant recombinant-proteins proteins protein

 

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