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TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
(Synonyms: Transforming growth factor β-3, Transforming growth factor beta-3, TGF-β-3, TGF-beta-3, TGFB3, Latency-associated peptide, LAP) Copy Product InfoSynonyms: Transforming growth factor β-3, Transforming growth factor beta-3, TGF-β-3, TGF-beta-3, TGFB3, Latency-associated peptide, LAP
Catalog No. TMPJ-00254 Copy Product Info
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $74 | 7-10 days | 7-10 days | |
| 10 μg | $118 | In Stock | In Stock | |
| 20 μg | $187 | 7-10 days | 7-10 days | |
| 50 μg | $350 | 7-10 days | 7-10 days | |
| 100 μg | $543 | 7-10 days | 7-10 days | |
| 200 μg | $843 | 7-10 days | 7-10 days | |
| 500 μg | $1,520 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:> 99.9%
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells. The ED50 for this effect is 10-80 pg/ml. (QC verified)  |
| Description | Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate. |
| Species | Human,Mouse,Rat |
| Expression System | HEK293 Cells |
| Tag | Tag Free |
| Accession Number | P10600 |
| Amino Acid | Ala301-Ser412(Tyr340Phe) |
| Construction | Ala301-Ser412(Tyr340Phe) |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified)  |
| Endotoxin | < 0.001 ng/µg (0.01 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Glycine-HCl, 150 mM NaCl, pH 2.5. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Transforming growth factor β-3, Transforming growth factor beta-3, TGF-β-3, TGF-beta-3, TGFB3, Latency-associated peptide, LAP |
| Research Background |
| Molecular Weight | 12-14 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: TGF beta 3 Protein, Human/Mouse/Rat, Recombinant chemical structure | TGF beta 3 Protein, Human/Mouse/Rat, Recombinant molecular weight
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