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BMV109

Name: BMV109
Brand: TargetMol
SKU: T85864
Rating: 4.5 (1 reviews)

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Catalog No. T85864Cas No. 1458731-58-2

Alias BMV-109, BMV109, BMV 109

BMV109 is a quenched probe designed to emit fluorescence upon being cleaved and covalently bound by active cathepsin proteases. This property of BMV109 is utilized in tumor imaging [1] [2].

BMV109

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Catalog No. T85864Alias BMV-109, BMV109, BMV 109Cas No. 1458731-58-2

BMV109 is a quenched probe designed to emit fluorescence upon being cleaved and covalently bound by active cathepsin proteases. This property of BMV109 is utilized in tumor imaging [1] [2].

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	3-6 months	3-6 months
50 mg	Inquiry	3-6 months	3-6 months
100 mg	Inquiry	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BMV109 is a quenched probe designed to emit fluorescence upon being cleaved and covalently bound by active cathepsin proteases. This property of BMV109 is utilized in tumor imaging [1] [2].
In vitro	BMV109 (compound 8; 0.05 µM, 0.1 µM, 0.5 µM, 1 µM, 5 µM) labels all target cysteine cathepsins (B, S, L, X) with equal intensity in live RAW cells [1].
In vivo	In a mouse model of breast cancer, BMV109 (Compound 8; 20 nmol; intravenous injection) achieved tumor-specific fluorescence signals [1]. Animal Model: Balb/c mice bearing 4T1 cells [1]. Dosage: 20 nmol. Administration: Tail vein. Result: High-intensity, tumor-specific fluorescence activation was observed.
Synonyms	BMV-109, BMV109, BMV 109

Chemical Properties

Molecular Weight	2138.37
Formula	C₁₀₇H₁₀₈F₄N₁₀O₂₃S₅
Cas No.	1458731-58-2
Smiles	S(=O)(=O)(C1=C(C=2C3=C([O+]=C4C2C=CC(=C4)N5C=6C(CC5)=CC(S(=O)(=O)O)=CC6)C=C(C=C3)N7C=8C(CC7)=CC(S(=O)(=O)[O-])=CC8)C=CC=C1)N9CCC(C(NCCNC(=O)C%10=C(F)C(F)=C(OCC([C@@H](NC([C@H](CC%11=CC=CC=C%11)NC(OCC%12=CC=CC=C%12)=O)=O)CCCCNC(CCCCCN%13C=%14C(C(C)(C)C%13=CC=CC=CC%15=[N+](CC)C=%16C(C%15(C)C)=CC(S(=O)(=O)[O-])=CC%16)=CC(S(=O)(=O)O)=CC%14)=O)=O)C(F)=C%10F)=O)CC9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc