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BMV109
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Catalog No. T85864Cas No. 1458731-58-2
Alias BMV-109, BMV109, BMV 109
BMV109 is a quenched probe designed to emit fluorescence upon being cleaved and covalently bound by active cathepsin proteases. This property of BMV109 is utilized in tumor imaging [1] [2].
BMV109
😃Good
Catalog No. T85864Alias BMV-109, BMV109, BMV 109Cas No. 1458731-58-2
BMV109 is a quenched probe designed to emit fluorescence upon being cleaved and covalently bound by active cathepsin proteases. This property of BMV109 is utilized in tumor imaging [1] [2].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | Inquiry | 3-6 months | 3-6 months | |
| 50 mg | Inquiry | 3-6 months | 3-6 months | |
| 100 mg | Inquiry | 3-6 months | 3-6 months |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | BMV109 is a quenched probe designed to emit fluorescence upon being cleaved and covalently bound by active cathepsin proteases. This property of BMV109 is utilized in tumor imaging [1] [2]. |
| In vitro | BMV109 (compound 8; 0.05 µM, 0.1 µM, 0.5 µM, 1 µM, 5 µM) labels all target cysteine cathepsins (B, S, L, X) with equal intensity in live RAW cells [1]. |
| In vivo | In a mouse model of breast cancer, BMV109 (Compound 8; 20 nmol; intravenous injection) achieved tumor-specific fluorescence signals [1]. Animal Model: Balb/c mice bearing 4T1 cells [1]. Dosage: 20 nmol. Administration: Tail vein. Result: High-intensity, tumor-specific fluorescence activation was observed. |
| Synonyms | BMV-109, BMV109, BMV 109 |
| Molecular Weight | 2138.37 |
| Formula | C107H108F4N10O23S5 |
| Cas No. | 1458731-58-2 |
| Smiles | S(=O)(=O)(C1=C(C=2C3=C([O+]=C4C2C=CC(=C4)N5C=6C(CC5)=CC(S(=O)(=O)O)=CC6)C=C(C=C3)N7C=8C(CC7)=CC(S(=O)(=O)[O-])=CC8)C=CC=C1)N9CCC(C(NCCNC(=O)C%10=C(F)C(F)=C(OCC([C@@H](NC([C@H](CC%11=CC=CC=C%11)NC(OCC%12=CC=CC=C%12)=O)=O)CCCCNC(CCCCCN%13C=%14C(C(C)(C)C%13=CC=CC=CC%15=[N+](CC)C=%16C(C%15(C)C)=CC(S(=O)(=O)[O-])=CC%16)=CC(S(=O)(=O)O)=CC%14)=O)=O)C(F)=C%10F)=O)CC9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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