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NF546 hydrate

Catalog No. T78079

NF546 (hydrate), a selective non-nucleotide P2Y11 agonist, exhibits a pEC50 value of 6.27 and induces interleukin-8 secretion from human monocyte-derived dendritic cells [1].

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NF546 hydrate, CAS N/A

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	NF546 (hydrate), a selective non-nucleotide P2Y11 agonist, exhibits a pEC50 value of 6.27 and induces interleukin-8 secretion from human monocyte-derived dendritic cells [1].
In vitro	NF546 (hydrate) exhibits relative selectivity for the P2Y11 subtype compared to P2Y1, P2Y2, P2Y4, P2Y6, P2Y12, P2X1, P2X2, and P2X2-X3 receptors. At a concentration of 100 μM and after 24 hours of treatment, NF546 (hydrate) demonstrates equivalent efficacy in promoting the secretion of TSP-1 and suppressing LPS-evoked IL-12p70 release in human monocyte-derived dendritic cells [1].

Molecular Weight	1424.01
Formula	C47H44N6Na4O17P4.13.5H2O

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

NF546 hydrate GPCR/G Protein Neuroscience P2Y Receptor inhibitor inhibit

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