keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ANG1005 is a brain-penetrating peptide-agent conjugate comprising a taxane derivative that features three paclitaxel molecules covalently bonded to Angiopep-2. This design facilitates crossing of the blood-brain and blood-cerebrospinal barriers, with subsequent penetration of malignant cells through the low-density lipoprotein receptor-related protein (LRP1) transport system [1] [2] [3].
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Description | ANG1005 is a brain-penetrating peptide-agent conjugate comprising a taxane derivative that features three paclitaxel molecules covalently bonded to Angiopep-2. This design facilitates crossing of the blood-brain and blood-cerebrospinal barriers, with subsequent penetration of malignant cells through the low-density lipoprotein receptor-related protein (LRP1) transport system [1] [2] [3]. |
In vivo | ANG1005 has shown a significantly improved brain delivery and therapeutic effect on breast cancer brain metastases [1] compared to free paclitaxel. |
Molecular Weight | 5127.33 |
Formula | C256H306N32O81 |
CAS No. | 1075214-55-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ANG1005 1075214-55-9 inhibitor inhibit