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Thiamine pyrophosphate chloride
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Catalog No. T4874Cas No. 154-87-0
Alias Thiamine pyrophosphate, cocarboxylase hydrochloride
Thiamine pyrophosphate (Cocarboxylase) is a vitamin B-1 derivative that acts as a coenzyme of transketolase. Thiamine pyrophosphate is used in studies to assess decarboxylation mechanisms in biological systems.
Thiamine pyrophosphate chloride
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Purity: 99.99%
Catalog No. T4874Alias Thiamine pyrophosphate, cocarboxylase hydrochlorideCas No. 154-87-0
Thiamine pyrophosphate (Cocarboxylase) is a vitamin B-1 derivative that acts as a coenzyme of transketolase. Thiamine pyrophosphate is used in studies to assess decarboxylation mechanisms in biological systems.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $31 | In Stock | In Stock | |
| 100 mg | $41 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.99%
Appearance:Solid
Color:White
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Product Introduction
Thiamine pyrophosphate chloride AI Summary
Thiamine pyrophosphate chloride exhibits various bioactivities, acting as both a competitive and noncompetitive inhibitor of electric eel acetylcholinesterase (AChE) with Ki values of 14,200,000 nM and 14,600,000 nM for competitive inhibition at pH 7 and pH 8.25, respectively, and Ki values of 6,740,000 nM and 58,400,000 nM for noncompetitive inhibition at the same pH levels. It also shows binding affinity to Deinococcus radiodurans DXS with a Kd of 114.0 nM and to Mycobacterium tuberculosis DXS with a Kd of 3100.0 nM. In terms of antiviral activity, Thiamine pyrophosphate chloride inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 6.74% at a concentration of 10 µM after 48 hours, according to high content imaging. However, it displays limited inhibition of the SARS-CoV-2 3CL-Pro protease (0.63% at 20 µM in a FRET assay) and shows 0.0% inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells under specific assay conditions..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Thiamine pyrophosphate (Cocarboxylase) is a vitamin B-1 derivative that acts as a coenzyme of transketolase. Thiamine pyrophosphate is used in studies to assess decarboxylation mechanisms in biological systems. |
| Synonyms | Thiamine pyrophosphate, cocarboxylase hydrochloride |
| Molecular Weight | 460.76 |
| Formula | C12H19ClN4O7P2S |
| Cas No. | 154-87-0 |
| Smiles | [Cl-].Cc1c(CCOP(O)(=O)OP(O)(O)=O)sc[n+]1Cc1cnc(C)nc1N |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 110 mg/mL (238.74 mM), Sonication is recommended.  DMSO: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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