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ZD 7155 hydrochloride

Name: ZD 7155 hydrochloride
Brand: TargetMol
SKU: T13390
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13390Cas No. 146709-78-6

ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

ZD 7155 hydrochloride

🥰Excellent

Purity: 99.8%

Catalog No. T13390Cas No. 146709-78-6

ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$80	In Stock
10 mg	$137	In Stock
25 mg	$247	In Stock
50 mg	$417	In Stock
100 mg	$669	In Stock
200 mg	$933	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock

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Batch Information

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Purity:99.8%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

In vivo

ZD 7155 (240 ng/kg ; 10 min infusion ; SD rats) is approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response.[1]
ZD 7155 (1.082 μmol/kg ; administered intravenously) and angiotensin II given at 240 ng/kg (in a 10-min infusion) could suppress the angiotensin II-induced pressor response.[1]
ZD 7155 (1.082 mumol/kg ; conscious SHRs) and losartan (6.495 mumol/kg) as intravenous boluses indicate that both ZD 7155 and the reference compound losartan exhibit a significant antihypertensive effect.[1]

Chemical Properties

Molecular Weight	474.98
Formula	C₂₆H₂₇ClN₆O
Cas No.	146709-78-6
Smiles	Cl.CCc1cc2N(Cc3ccc(cc3)-c3ccccc3-c3nn[nH]n3)C(=O)CCc2c(CC)n1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 3.8 mg/mL (7.9 mM ), Sonication and heating to 60℃ are recommended.

DMSO: 225.0 mg/mL (473.7 mM ), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1054 mL	10.5268 mL	21.0535 mL	105.2676 mL
5 mM	0.4211 mL	2.1054 mL	4.2107 mL	21.0535 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2105 mL	1.0527 mL	2.1054 mL	10.5268 mL
20 mM	0.1053 mL	0.5263 mL	1.0527 mL	5.2634 mL
50 mM	0.0421 mL	0.2105 mL	0.4211 mL	2.1054 mL
100 mM	0.0211 mL	0.1053 mL	0.2105 mL	1.0527 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc