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Elgemtumab
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Catalog No. T77176Cas No. 1512559-37-3
Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation and exhibiting antitumour activity.
Elgemtumab
Elgemtumab
😃Good
Catalog No. T77176Cas No. 1512559-37-3
Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation and exhibiting antitumour activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $290 | - | In Stock | |
| 5 mg | $755 | - | In Stock | |
| 10 mg | $1,200 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.9% (SDS-PAGE); 96.1% (SEC-HPLC)
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| Description | Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation and exhibiting antitumour activity. |
| In vivo | Methods: Elgemtumab was administered as a single intravenous injection at 20 mg/kg in SCID mice bearing BT474 and BxPC-3 xenografts; in NSG mice bearing BT474 xenografts, it was given every other day at 20 mg/kg for 35 days. Results: Elgemtumab significantly inhibited pHER3 and pAKT levels in both BT474 and BxPC-3 models and slowed tumor growth in the BT474 model. [1] |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ERBB3/HER3 |
| Molecular Weight | 144.15 kDa |
| Cas No. | 1512559-37-3 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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