Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 is a potent inhibitor of NLRP3 and AIM2 inflammasome-dependent cell lysis with an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 inhibits LPS/nigericin NLRP3/AIM2-IN-3 inhibits LPS/nigericin-stimulated cell lysis in THP-1 macrophages with an IC50 value of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC, inhibiting oligomerization of ASC.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 68.00 | |
10 mg | In stock | $ 109.00 | |
25 mg | In stock | $ 228.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 597.00 | |
500 mg | In stock | $ 1,260.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 75.00 |
Description | NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 is a potent inhibitor of NLRP3 and AIM2 inflammasome-dependent cell lysis with an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 inhibits LPS/nigericin NLRP3/AIM2-IN-3 inhibits LPS/nigericin-stimulated cell lysis in THP-1 macrophages with an IC50 value of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC, inhibiting oligomerization of ASC. |
In vitro |
NLRP3/AIM2-IN-3 (0-100 μM) exhibits significant inhibitory activity against NLRP3 and AIM2, but not NLRC4-dependent activation of caspase-1 and release of IL-1b in human THP-1 macrophages Significant inhibitory effect.[1] NLRP3/AIM2-IN-3 inhibits IL-1b secretion from human THP-1 macrophages with IC50 of 0.098 μM, nearly 150-fold and 500-fold more potent than NLRP3/AIM2-IN-3 for J774A.1 (14.62 μM) and Bone marrow-derived macrophages (BMDM) (48.98 μM).[1] |
Molecular Weight | 266.29 |
Formula | C16H14N2O2 |
CAS No. | 1787787-60-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (844.9 mM), Sonication is recommended.
Methanol: 45.0 mg/mL (169.0 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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NLRP3/AIM2-IN-3 1787787-60-3 Immunology/Inflammation NF-Κb NOD AIM2 inhibitor inhibit