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GPX4-IN-3

Name: GPX4-IN-3
Brand: TargetMol
SKU: T63729
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63729Cas No. 2761004-85-5

GPX4-IN-3 (26a) is a potent inhibitor of glutathione peroxidase 4 (GPX4), selectively inducing ferroptosis. It demonstrates a 71.7% inhibition rate of GPX4 at a concentration of 1 μM .

GPX4-IN-3

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Purity: 99.91%

Catalog No. T63729Cas No. 2761004-85-5

GPX4-IN-3 (26a) is a potent inhibitor of glutathione peroxidase 4 (GPX4), selectively inducing ferroptosis. It demonstrates a 71.7% inhibition rate of GPX4 at a concentration of 1 μM .

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
5 mg	$179	-	In Stock
10 mg	$347	-	In Stock
25 mg	$695	-	In Stock
50 mg	$1,090	-	In Stock
1 mL x 10 mM (in DMSO)	$209	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.91%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	GPX4-IN-3 (26a) is a potent inhibitor of glutathione peroxidase 4 (GPX4), selectively inducing ferroptosis. It demonstrates a 71.7% inhibition rate of GPX4 at a concentration of 1 μM .
In vitro	The IC50 values of GPX4-IN-3 (26a) in 4T1, MCF-7, HT1080, and HT1080 (Fer‑1 treated) cells are 0.78 μM, 6.9 μM, 0.15 μM, and 4.73 μM, respectively [1]. GPX4-IN-3 (26a) exhibits excellent GPX4 inhibitory activity, with an inhibition rate of 71.7% at 1.0 μM, compared with 45.9% for RSL‑3 [1]. GPX4-IN-3 (26a) shows favorable selectivity and significantly increases lipid peroxide (LPO) levels, effectively inducing ferroptosis [1]. GPX4-IN-3 (26a) induces ferroptosis most likely by inhibiting GPX4 activity and promoting the accumulation of intracellular peroxides [1]. GPX4-IN-3 (26a) significantly increases ROS levels in 4T1 cells, and this effect can be reversed by Ferrostatin‑1 (fer‑1) [1].
In vivo	GPX4-IN-3 (26a) exhibits antitumor activity and favorable biosafety in vivo [1].

Chemical Properties

Molecular Weight	530.04
Formula	C₂₉H₂₄ClN₃O₃S
Cas No.	2761004-85-5
Smiles	O=C(NCCC=1C=CC=CC1)C(C2=CSC=3C=CC=CC32)N(C=4C=CC(=CC4)C=5OC=NC5)C(=O)CCl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 54 mg/mL (101.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8867 mL	9.4333 mL	18.8665 mL	94.3325 mL
5 mM	0.3773 mL	1.8867 mL	3.7733 mL	18.8665 mL
10 mM	0.1887 mL	0.9433 mL	1.8867 mL	9.4333 mL
20 mM	0.0943 mL	0.4717 mL	0.9433 mL	4.7166 mL
50 mM	0.0377 mL	0.1887 mL	0.3773 mL	1.8867 mL
100 mM	0.0189 mL	0.0943 mL	0.1887 mL	0.9433 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

GPX4-IN-3

GPX4-IN-3

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In Vivo Formulation Calculator (Clear solution)

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