Shopping Cart

Your shopping cart is currently empty

XL01126

Name: XL01126
Brand: TargetMol
SKU: T74638
Price: 350 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: XL 01126) Copy Product Info

🥰Excellent

Synonyms: XL 01126

Catalog No. T74638 Copy Product Info

Purity: 99.98%

🥰Excellent

XL01126 is a potent degrader of leucine-rich repeat kinase 2 (LRRK2), exhibiting DC50 values of 14 nM for G2019S LRRK2 and 32 nM for wild-type LRRK2. XL01126 is capable of crossing the blood-brain barrier and serves as a degrader probe for Parkinson’s disease research. XL01126 is also a valuable molecular tool for investigating the non-catalytic and scaffolding functions of LRRK2. These properties support the utilization of XL01126 in studies of protein degradation technologies, neurodegenerative disease biology, and LRRK2-mediated cellular signaling pathways.

Cas No. 3011029-58-3

Pack Size	Price	USA Stock	Global Stock
1 mg	$350	-	In Stock
5 mg	$720	-	In Stock
10 mg	$1,070	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Synonyms

XL 01126

Chemical Properties

Molecular Weight	1019.69
Formula	C₅₀H₆₄ClFN₁₀O₆S₂
Cas No.	3011029-58-3
Smiles	C([C@@H](NC(=O)C1(F)CC1)C(SC[C@H]2CC[C@H](CN3CCN(C(=O)C4=CC(OC)=C(NC=5N=C(NC)C(Cl)=CN5)C=C4)CC3)CC2)(C)C)(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (78.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9807 mL	4.9035 mL	9.8069 mL	49.0345 mL
5 mM	0.1961 mL	0.9807 mL	1.9614 mL	9.8069 mL
10 mM	0.0981 mL	0.4903 mL	0.9807 mL	4.9035 mL
20 mM	0.0490 mL	0.2452 mL	0.4903 mL	2.4517 mL
50 mM	0.0196 mL	0.0981 mL	0.1961 mL	0.9807 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: XL01126 chemical structure | XL01126 formula | XL01126 molecular weight