Shopping Cart
Remove All
Your shopping cart is currently empty
MK-8527
😃Good
Catalog No. T86907Cas No. 1810869-23-8
Alias MK8527
MK-8527 is an orally active HIV-1 inhibitor and nucleoside reverse transcriptase translocation inhibitor with an IC₅₀ of 0.21 nM. It is phosphorylated intracellularly to its active triphosphate form, exhibiting antiviral activity.
MK-8527
😃Good
Purity: 99.15%
Catalog No. T86907Alias MK8527Cas No. 1810869-23-8
MK-8527 is an orally active HIV-1 inhibitor and nucleoside reverse transcriptase translocation inhibitor with an IC₅₀ of 0.21 nM. It is phosphorylated intracellularly to its active triphosphate form, exhibiting antiviral activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $118 | - | In Stock | |
| 2 mg | $176 | - | In Stock | |
| 5 mg | $297 | - | In Stock | |
| 10 mg | $476 | - | In Stock | |
| 25 mg | $953 | - | In Stock | |
| 50 mg | $1,480 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $327 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.15%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MK-8527 is an orally active HIV-1 inhibitor and nucleoside reverse transcriptase translocation inhibitor with an IC₅₀ of 0.21 nM. It is phosphorylated intracellularly to its active triphosphate form, exhibiting antiviral activity. |
| In vitro | MK-8527 inhibits viral replication in human peripheral blood mononuclear cells (PBMCs), with a half maximal inhibitory concentration (IC50) of 0.21 nM [5]. |
| In vivo | The pharmacokinetic (PK) profile of MK-8527 in rats and rhesus monkeys was characterized by low-to-moderate clearance and volume of distribution, with good oral absorption (57% and 100% in rats and monkeys, respectively). Following oral administration of MK-8527 to monkeys, MK-8527-TP exhibited an intracellular half-life of approximately 48 h in PBMCs, significantly longer than the apparent plasma half-life of the parent compound (approximately 7 h) [5]. |
| Synonyms | MK8527 |
| Molecular Weight | 308.72 |
| Formula | C13H13ClN4O3 |
| Cas No. | 1810869-23-8 |
| Smiles | NC1=C2C(N(C=C2)[C@@H]3O[C@](C#C)(CO)[C@@H](O)C3)=NC(Cl)=N1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (291.53 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy MK-8527 | purchase MK-8527 | MK-8527 cost | order MK-8527 | MK-8527 chemical structure | MK-8527 in vivo | MK-8527 in vitro | MK-8527 formula | MK-8527 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.