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MK-8527
🥰Excellent
Catalog No. T86907Cas No. 1810869-23-8
Alias MK8527
MK-8527 is an orally active HIV-1 inhibitor and nucleoside reverse transcriptase translocation inhibitor with an IC₅₀ of 0.21 nM. It is phosphorylated intracellularly to its active triphosphate form, exhibiting antiviral activity.
MK-8527
🥰Excellent
Purity: 99.15%
Catalog No. T86907Alias MK8527Cas No. 1810869-23-8
MK-8527 is an orally active HIV-1 inhibitor and nucleoside reverse transcriptase translocation inhibitor with an IC₅₀ of 0.21 nM. It is phosphorylated intracellularly to its active triphosphate form, exhibiting antiviral activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $118 | - | In Stock | |
| 2 mg | $176 | - | In Stock | |
| 5 mg | $297 | - | In Stock | |
| 10 mg | $476 | - | In Stock | |
| 25 mg | $953 | - | In Stock | |
| 50 mg | $1,480 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $327 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.15%
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Product Introduction
Bioactivity
Chemical Properties
| Description | MK-8527 is an orally active HIV-1 inhibitor and nucleoside reverse transcriptase translocation inhibitor with an IC₅₀ of 0.21 nM. It is phosphorylated intracellularly to its active triphosphate form, exhibiting antiviral activity. |
| In vitro | MK-8527 inhibits viral replication in human peripheral blood mononuclear cells (PBMCs), with a half maximal inhibitory concentration (IC50) of 0.21 nM [5]. |
| In vivo | The pharmacokinetic (PK) profile of MK-8527 in rats and rhesus monkeys was characterized by low-to-moderate clearance and volume of distribution, with good oral absorption (57% and 100% in rats and monkeys, respectively). Following oral administration of MK-8527 to monkeys, MK-8527-TP exhibited an intracellular half-life of approximately 48 h in PBMCs, significantly longer than the apparent plasma half-life of the parent compound (approximately 7 h) [5]. |
| Synonyms | MK8527 |
| Molecular Weight | 308.72 |
| Formula | C13H13ClN4O3 |
| Cas No. | 1810869-23-8 |
| Smiles | NC1=C2C(N(C=C2)[C@@H]3O[C@](C#C)(CO)[C@@H](O)C3)=NC(Cl)=N1 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (291.53 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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