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4-oxo Withaferin A

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Catalog No. T36893Cas No. 6850-30-2

4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.

4-oxo Withaferin A

4-oxo Withaferin A

😃Good
Catalog No. T36893Cas No. 6850-30-2
4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.
Pack SizePriceAvailabilityQuantity
1 mg$31635 days
5 mg$1,09035 days
10 mg$1,72035 days
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Product Introduction

Bioactivity
Description
4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.
Chemical Properties
Molecular Weight468.59
FormulaC28H36O6
Cas No.6850-30-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 5 mg/mL (10.67 mM), Sonication is recommended.
DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL (1.07 mM), Sonication is recommended.
DMF: 5 mg/mL (10.67 mM), Sonication is recommended.
Solution Preparation Table
DMSO/DMF
1mg5mg10mg50mg
5 mM0.4268 mL2.1341 mL4.2681 mL21.3406 mL
10 mM0.2134 mL1.0670 mL2.1341 mL10.6703 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

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