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(S)-Bromoenol lactone
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Catalog No. T60832Cas No. 478288-94-7
Alias (S,E)-Bromoenol lactone, (S)-BEL
(S)-Bromoenol lactone ((S)-BEL) is a mechanism-based, irreversible inhibitor of calcium-independent phospholipase A2 (iPLA2). In contrast to its enantiomer (R)-BEL, (S)-BEL exhibits a preference for iPLA2γ (Group VIB), typically being about 10- to 100-fold more potent at inhibiting iPLA2γ than iPLA2β (Group VIA). This compound, used in conjunction with (R)-BEL, is a critical pharmacological tool for discriminating the specific functions of iPLA2β versus iPLA2γ in processes such as cellular signaling, arachidonic acid release, and smooth muscle contraction.
(S)-Bromoenol lactone
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Catalog No. T60832Alias (S,E)-Bromoenol lactone, (S)-BELCas No. 478288-94-7
(S)-Bromoenol lactone ((S)-BEL) is a mechanism-based, irreversible inhibitor of calcium-independent phospholipase A2 (iPLA2). In contrast to its enantiomer (R)-BEL, (S)-BEL exhibits a preference for iPLA2γ (Group VIB), typically being about 10- to 100-fold more potent at inhibiting iPLA2γ than iPLA2β (Group VIA). This compound, used in conjunction with (R)-BEL, is a critical pharmacological tool for discriminating the specific functions of iPLA2β versus iPLA2γ in processes such as cellular signaling, arachidonic acid release, and smooth muscle contraction.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 μg | $113 | - | In Stock | |
| 1 mg | $198 | 35 days | 35 days | |
| 5 mg | $833 | 35 days | 35 days | |
| 10 mg | $1,320 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | (S)-Bromoenol lactone ((S)-BEL) is a mechanism-based, irreversible inhibitor of calcium-independent phospholipase A2 (iPLA2). In contrast to its enantiomer (R)-BEL, (S)-BEL exhibits a preference for iPLA2γ (Group VIB), typically being about 10- to 100-fold more potent at inhibiting iPLA2γ than iPLA2β (Group VIA). This compound, used in conjunction with (R)-BEL, is a critical pharmacological tool for discriminating the specific functions of iPLA2β versus iPLA2γ in processes such as cellular signaling, arachidonic acid release, and smooth muscle contraction. |
| Synonyms | (S,E)-Bromoenol lactone, (S)-BEL |
| Molecular Weight | 317.18 |
| Formula | C16H13BrO2 |
| Cas No. | 478288-94-7 |
| Smiles | O=C1[C@H](C=2C3=C(C=CC2)C=CC=C3)CC/C(=C\Br)/O1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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