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3-MeOARh-NTR

Name: 3-MeOARh-NTR
Brand: TargetMol
SKU: T78420
Rating: 4.5 (1 reviews)

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Catalog No. T78420

3-MeOARh-NTR is an activatable imaging probe characterized by high selectivity and stability, offering a high signal-to-noise ratio specifically for nitroreductase (NTR) detection. It serves as an efficient molecular tool for identifying endogenous NTR [1].

3-MeOARh-NTR

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Catalog No. T78420

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

In vitro

The chemical compound 3-MeOARh-NTR at a concentration of 10 μM with a 30-minute incubation time produced a strong fluorescent signal in live HeLa cells subjected to hypoxia by pre-incubation in 20% and 10% O₂ for 12 hours [1]. Additionally, the same concentration of 3-MeOARh-NTR facilitated fluorescence imaging in mouse kidney tissue, utilizing an excitation wavelength of 488 nm and emission range of 510-590 nm. 3-MeOARh-NTR is an effective probe for detecting and evaluating renal hypoxia via NTR assessment [1].

Chemical Properties

Formula

C₃₃H₃₀N₃O₈+

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc