Optineurin Protein, Human, Recombinant (His)

Name: Optineurin Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPH-01814
Rating: 4.5 (1 reviews)

(Synonyms: Transcription factor IIIA-interacting protein (TFIIIA-IntP), OPTN, Optineurin, Optic neuropathy-inducing protein, NRP, NEMO-related protein, HYPL, Huntingtin-interacting protein L, Huntingtin-interacting protein 7 (HIP-7), Huntingtin yeast partner L, HIP7, GLC1E, FIP2, E3-14.7K-interacting protein (FIP-2)) Copy Product Info

Synonyms: Transcription factor IIIA-interacting protein (TFIIIA-IntP), OPTN, Optineurin, Optic neuropathy-inducing protein, NRP, NEMO-related protein, HYPL, Huntingtin-interacting protein L, Huntingtin-interacting protein 7 (HIP-7), Huntingtin yeast partner L, HIP7, GLC1E, FIP2, E3-14.7K-interacting protein (FIP-2)

Catalog No. TMPH-01814 Copy Product Info

Optineurin Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with C-9xHis tag. The predicted molecular weight is 68.0 kDa and the accession number is Q96CV9.

Pack Size	Price	USA Stock	Global Stock
5 µg	$176	20 days	20 days
10 µg	$292	20 days	20 days
20 µg	$489	20 days	20 days
50 µg	$923	20 days	20 days
100 µg	$1,500	20 days	20 days
200 µg	$1,890	20 days	20 days
500 µg	$2,580	20 days	20 days
1 mg	$3,260	20 days	20 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Optineurin Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with C-9xHis tag. The predicted molecular weight is 68.0 kDa and the accession number is Q96CV9.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	C-9xHis
Accession Number	Q96CV9
Amino Acid	MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSKAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
Construction	1-577 aa
Protein Purity	> 85% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Tris-based buffer, 50% glycerol
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	Transcription factor IIIA-interacting protein (TFIIIA-IntP), OPTN, Optineurin, Optic neuropathy-inducing protein, NRP, NEMO-related protein, HYPL, Huntingtin-interacting protein L, Huntingtin-interacting protein 7 (HIP-7), Huntingtin yeast partner L, HIP7, GLC1E, FIP2, E3-14.7K-interacting protein (FIP-2)
Research Background	Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.; (Microbial infection) May constitute a cellular target for adenovirus E3 14.7 and Bluetongue virus protein NS3 to inhibit innate immune response.

Chemical Properties

Molecular Weight

68.0 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.