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MitoTEMPO hydrate

Name: MitoTEMPO hydrate
Brand: TargetMol
SKU: T35964
Rating: 4.5 (1 reviews)

Catalog No. T35964 Copy Product Info

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MitoTEMPO hydrate is a mitochondria-targeted antioxidant and superoxide scavenger. It mimics SOD activity to protect against mitochondrial oxidative stress in hypertension and neurodegeneration research.

MitoTEMPO hydrate

Copy Product Info

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Catalog No. T35964

Cas No. 1569257-94-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$113	35 days	35 days
5 mg	$253	35 days	35 days
10 mg	$426	35 days	35 days
25 mg	$968	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	MitoTEMPO hydrate is a mitochondria-targeted antioxidant and superoxide scavenger. It mimics SOD activity to protect against mitochondrial oxidative stress in hypertension and neurodegeneration research.
In vitro	MitoTEMPO hydrate scavenges mitochondrial superoxide to inhibit mPTP opening, reducing necrosis and apoptosis in renal and endothelial cells [2][4].
In vivo	In hypertensive mice, MitoTEMPO hydrate significantly lowers blood pressure and improves endothelium-dependent vasodilation by scavenging mitochondrial superoxide [3].

Chemical Properties

Molecular Weight	528.04
Formula	C₂₉H₃₇ClN₂O₃P
Cas No.	1569257-94-8
Smiles	O=C(NC1CC(C)(C)N([O])C(C)(C)C1)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Cl-].O
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (9.47 mM), Sonication is recommmended.

PBS (pH 7.2): < 1 mg/mL (insoluble), Sonication is recommended.

Ethanol: 7.5 mg/mL (14.2 mM), Sonication is recommmended.

DMF: 7.5 mg/mL (14.2 mM), Sonication is recommmended.

Solution Preparation Table

DMSO/Ethanol/DMF

	1mg	5mg	10mg	50mg
1 mM	1.8938 mL	9.4690 mL	18.9380 mL	94.6898 mL
5 mM	0.3788 mL	1.8938 mL	3.7876 mL	18.9380 mL

Ethanol/DMF

	1mg	5mg	10mg	50mg
10 mM	0.1894 mL	0.9469 mL	1.8938 mL	9.4690 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc