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2,3-Dehydrokievitone
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Catalog No. TN1204Cas No. 74161-25-4
2,3-Dehydrokievitone, an isoflavone extracted from Erythrina sacleuxii, has antimicrobial activity against methicillin-resistant Staphylococcus aureus infections by decreasing the expression of α-hemolysin.
2,3-Dehydrokievitone
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Purity: 99.91%
Catalog No. TN1204Cas No. 74161-25-4
2,3-Dehydrokievitone, an isoflavone extracted from Erythrina sacleuxii, has antimicrobial activity against methicillin-resistant Staphylococcus aureus infections by decreasing the expression of α-hemolysin.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $97 | - | In Stock | |
| 5 mg | $255 | - | In Stock | |
| 10 mg | $413 | - | In Stock | |
| 25 mg | $688 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.91%
Appearance:Solid
Color:Yellow
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Product Introduction
2,3-Dehydrokievitone AI Summary
2,3-Dehydrokievitone demonstrates a variety of bioactivities. It shows growth inhibition in several human cell lines, specifically MCF7 (GI = 31.0%), SW480 (GI = 13.0%), and HepG2 (GI = 5.0%) at 10 µM after 24 hours via MTS assay. In terms of anti-inflammatory properties, it inhibits LPS-induced NO production in mouse RAW264.7 cells by 9.0% at 10 µM after 24 hours. Additionally, it inhibits NF-kappaB transcription in human SW480 cells by 8.0% at 10 µM using a luciferase reporter gene assay.
The compound also inhibits specific enzymes, such as recombinant human PTP1B (34.0% inhibition at 10 µM after 30 minutes) and mushroom tyrosinase (up to 49.6% at 10 µM), particularly using L-tyrosine as a substrate. It has been observed to activate Nrf2 in human HepG2 cells with a 2.1-fold change compared to the untreated control, as determined by an ARE-driven luciferase reporter gene assay at 10 µM. Lastly, it exhibits additional antiproliferative activities against human A549 cells (4.2%) and human MCF7 cells (7.4%) at 10 µM.
In summary, 2,3-Dehydrokievitone possesses notable bioactivities including antiproliferative, anti-inflammatory, enzyme inhibition, and transcription factor modulation effects..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 2,3-Dehydrokievitone, an isoflavone extracted from Erythrina sacleuxii, has antimicrobial activity against methicillin-resistant Staphylococcus aureus infections by decreasing the expression of α-hemolysin. |
| Molecular Weight | 354.35 |
| Formula | C20H18O6 |
| Cas No. | 74161-25-4 |
| Smiles | O=C1C(=COC=2C1=C(O)C=C(O)C2CC=C(C)C)C=3C=CC(O)=CC3O |
| Relative Density. | 1.424 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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