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BrBzGCp2

Name: BrBzGCp2
Brand: TargetMol
SKU: T24598
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24598Cas No. 166038-00-2

Alias S-p-Bromobenzylglutathione cyclopentyl diester, pBrBzGSH(Cp)2, p BrBzGSH(Cp)2, BBGD, BBGC

BrBzGCp2 (p BrBzGSH(Cp)2) is an inhibitor of glyoxalase 1 (GLO1) with antitumor and neuroprotective activity. It can alleviate anxiety and be used in neurodegenerative disease research.

BrBzGCp2

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Purity: 98.68%

Catalog No. T24598Alias S-p-Bromobenzylglutathione cyclopentyl diester, pBrBzGSH(Cp)2, p BrBzGSH(Cp)2, BBGD, BBGCCas No. 166038-00-2

BrBzGCp2 (p BrBzGSH(Cp)2) is an inhibitor of glyoxalase 1 (GLO1) with antitumor and neuroprotective activity. It can alleviate anxiety and be used in neurodegenerative disease research.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$69	-	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.68%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	BrBzGCp2 (p BrBzGSH(Cp)2) is an inhibitor of glyoxalase 1 (GLO1) with antitumor and neuroprotective activity. It can alleviate anxiety and be used in neurodegenerative disease research.
Targets&IC50	Glyoxalase I:4.23 μM (GC50)
In vitro	BrBzGCp2 is an inhibitor of glyoxalase 1 (GLO1) with a GC50 of 4.23 μM in HL-60 cells. [1]
In vivo	BrBzGCp2 demonstrated an increase in dwell time in the central region of mice in open field (OF) experiments, while not significantly altering the distance traveled. GLO1 inhibition attenuated anxiety-like behavior by increasing methylglyoxal (MG) concentration. [2] Pretreatment with BrBzGCp2 shortens seizure duration. [3] BrBzGCp2 injections reduced anxiety levels in mice, and less anxiety and fear led to a greater willingness to explore unknown regions, suggesting that inhibition of GLO1 activity has a positive effect on anxiety relief. Treatment with BrBzGCp2 also restored the inhibitory effect of valproic acid (VPA) on GABAA receptor activation. [4]
Synonyms	S-p-Bromobenzylglutathione cyclopentyl diester, pBrBzGSH(Cp)2, p BrBzGSH(Cp)2, BBGD, BBGC

Chemical Properties

Molecular Weight	612.58
Formula	C₂₇H₃₈BrN₃O₆S
Cas No.	166038-00-2
Smiles	[C@H](CSCC1=CC=C(Br)C=C1)(C(NCC(OC2CCCC2)=O)=O)NC(CC[C@@H](C(OC3CCCC3)=O)N)=O
Relative Density.	1.31g/cm3
Sequence	H-gGlu(OcPent)-Cys(Bn(4-Br))-Gly-OcPent
Sequence Short	XXG

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (326.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6324 mL	8.1622 mL	16.3244 mL	81.6220 mL
5 mM	0.3265 mL	1.6324 mL	3.2649 mL	16.3244 mL
10 mM	0.1632 mL	0.8162 mL	1.6324 mL	8.1622 mL
20 mM	0.0816 mL	0.4081 mL	0.8162 mL	4.0811 mL
50 mM	0.0326 mL	0.1632 mL	0.3265 mL	1.6324 mL
100 mM	0.0163 mL	0.0816 mL	0.1632 mL	0.8162 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc