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Autotaxin-IN-6

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Catalog No. T72837Cas No. 2800898-98-8

Autotaxin-IN-6 (compound 23) is a potent inhibitor of autotaxin (ATX), exhibiting an IC50 of 30 nM, and attenuates cell migration with potential applications in anticancer research [1].

Autotaxin-IN-6

Autotaxin-IN-6

😃Good
Catalog No. T72837Cas No. 2800898-98-8
Autotaxin-IN-6 (compound 23) is a potent inhibitor of autotaxin (ATX), exhibiting an IC50 of 30 nM, and attenuates cell migration with potential applications in anticancer research [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Autotaxin-IN-6 (compound 23) is a potent inhibitor of autotaxin (ATX), exhibiting an IC50 of 30 nM, and attenuates cell migration with potential applications in anticancer research [1].
Targets&IC50
ATX:30 nM
In vitro
Autotaxin-IN-6 (compound 23) effectively inhibits ATX-induced activity in HeLa cells, significantly reducing LPA1 internalization by approximately 75% [1], while also impeding LPA1 activation and disrupting downstream Gαi- and PI3K-dependent signaling pathways [1].
Chemical Properties
Molecular Weight595.62
FormulaC35H54BNO6
Cas No.2800898-98-8
SmilesB(C1=CC=C(C=C1)OC2CCN(CC2)C(=O)CC[C@@H](C)C3CCC4[C@@]3(CCC5C4[C@H](CC6[C@@]5(CC[C@H](C6)O)C)O)C)(O)O.CC
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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