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PDE4-IN-20

🥰Excellent
Catalog No. T50023Cas No. 223500-15-0

ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, also known as EAPT, is a potent and selective PDE4 inhibitor that regulates intracellular cyclic adenosine monophosphate (cAMP) levels. It has been used in a variety of scientific applications, including the study of cAMP-mediated signaling pathways, and has potential as a therapeutic agent for the treatment of inflammatory and immune-related diseases.

PDE4-IN-20

PDE4-IN-20

🥰Excellent
Purity: 98.84%
Catalog No. T50023Cas No. 223500-15-0
ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, also known as EAPT, is a potent and selective PDE4 inhibitor that regulates intracellular cyclic adenosine monophosphate (cAMP) levels. It has been used in a variety of scientific applications, including the study of cAMP-mediated signaling pathways, and has potential as a therapeutic agent for the treatment of inflammatory and immune-related diseases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$32In StockIn Stock
10 mg$47In StockIn Stock
25 mg$82In StockIn Stock
50 mg$119In StockIn Stock
100 mg$179In StockIn Stock
200 mg$273In StockIn Stock
1 mL x 10 mM (in DMSO)$40In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.84%
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Product Introduction

Bioactivity
Description
ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, also known as EAPT, is a potent and selective PDE4 inhibitor that regulates intracellular cyclic adenosine monophosphate (cAMP) levels. It has been used in a variety of scientific applications, including the study of cAMP-mediated signaling pathways, and has potential as a therapeutic agent for the treatment of inflammatory and immune-related diseases.
Chemical Properties
Molecular Weight299.25
FormulaC13H12F3N3O2
Cas No.223500-15-0
SmilesC(F)(F)(F)C=1N(N=CC1C(OCC)=O)C2=CC=C(N)C=C2
Relative Density.1.39 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (150.38 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3417 mL16.7084 mL33.4169 mL167.0844 mL
5 mM0.6683 mL3.3417 mL6.6834 mL33.4169 mL
10 mM0.3342 mL1.6708 mL3.3417 mL16.7084 mL
20 mM0.1671 mL0.8354 mL1.6708 mL8.3542 mL
50 mM0.0668 mL0.3342 mL0.6683 mL3.3417 mL
100 mM0.0334 mL0.1671 mL0.3342 mL1.6708 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

ethyl 1(4aminophenyl)5(trifluoromethyl)1Hpyrazole4carboxylateethyl 1 (4 aminophenyl) 5 (trifluoromethyl) 1H pyrazole 4 carboxylate
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