Anti-inflammatory agent 47

Name: Anti-inflammatory agent 47
Brand: TargetMol
SKU: T79480
Rating: 4.5 (1 reviews)

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Catalog No. T79480Cas No. 2925288-12-4

Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson's Disease (PD) research [1].

Anti-inflammatory agent 47

😃Good

Catalog No. T79480Cas No. 2925288-12-4

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson's Disease (PD) research [1].
In vitro	Compound Flo8, at concentrations of 5 μM and 10 μM administered for 18 hours, exhibited minimal inhibitory effects on the viability of BV2 microglial cells [1]. Furthermore, at a concentration of 5 μM over 18 hours, it significantly inhibited the production of reactive oxygen species (ROS) in BV2 cells [1]. The same concentrations of Compound Flo8 over 18 hours also reduced the expression of inflammatory cytokines in BV2 cells, consequently decreasing apoptosis levels in SH-SY5Y cells [1]. Additionally, Compound Flo8 inhibited M1 polarization and promoted M2 polarization in microglia following LPS induction at 5 μM and 10 μM for 18 hours [1]. It also suppressed the phosphorylation of ERK, p38, and JNK in BV2 cells induced by LPS [1].
In vivo	Compound Flo8 (15/35 mg/kg, intraperitoneal injection, daily/biweekly) alleviates neuroinflammation and inhibits neuronal apoptosis in the brains of MPTP-induced C57BL/6J mice [1].

Chemical Properties

Molecular Weight	394.42
Formula	C₂₅H₁₈N₂O₃
Cas No.	2925288-12-4
Smiles	O=C1C=2C(=C(C=CC2)C3=NC(=NO3)C4=CC(C)=CC=C4)OC(=C1C)C5=CC=CC=C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc