This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Anti-inflammatory agent 47
Catalog No. T79480 CAS
2925288-12-4
Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson's Disease (PD) research [1].
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson's Disease (PD) research [1].
In vitro
Compound Flo8, at concentrations of 5 μM and 10 μM administered for 18 hours, exhibited minimal inhibitory effects on the viability of BV2 microglial cells [1]. Furthermore, at a concentration of 5 μM over 18 hours, it significantly inhibited the production of reactive oxygen species (ROS) in BV2 cells [1]. The same concentrations of Compound Flo8 over 18 hours also reduced the expression of inflammatory cytokines in BV2 cells, consequently decreasing apoptosis levels in SH-SY5Y cells [1]. Additionally, Compound Flo8 inhibited M1 polarization and promoted M2 polarization in microglia following LPS induction at 5 μM and 10 μM for 18 hours [1]. It also suppressed the phosphorylation of ERK, p38, and JNK in BV2 cells induced by LPS [1].
In vivo
Compound Flo8 (15/35 mg/kg, intraperitoneal injection, daily/biweekly) can alleviate neuroinflammation and inhibit neuronal apoptosis in the brains of C57BL/6J mice induced by MPTP [1].
Molecular Weight
394.42
Formula
C25H18N2O3
CAS No.
2925288-12-4
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.