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N4-Acetyl-2'-O-methylcytidine

Name: N4-Acetyl-2'-O-methylcytidine
Brand: TargetMol
SKU: TN7736
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN7736Cas No. 113886-71-8

N4-Acetyl-2'-O-methylcytidine (ac4Cm) is a doubly modified RNA nucleoside bearing both N4-acetylation and 2'-O-methylation that is predominantly identified in thermophilic archaea. N4-Acetyl-2'-O-methylcytidine contributes to molecular adaptation under extreme environmental conditions by enhancing RNA structural stability, resistance to thermal degradation, and translational fidelity through synergistic chemical modification.

N4-Acetyl-2'-O-methylcytidine

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Purity: 99.62%

Catalog No. TN7736Cas No. 113886-71-8

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	-	In Stock
500 mg	$59	-	In Stock
1 mL x 10 mM (in DMSO)	$48	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.62%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	299.28
Formula	C₁₂H₁₇N₃O₆
Cas No.	113886-71-8
Smiles	O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(NC(C)=O)C=C2

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (267.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3414 mL	16.7068 mL	33.4135 mL	167.0676 mL
5 mM	0.6683 mL	3.3414 mL	6.6827 mL	33.4135 mL
10 mM	0.3341 mL	1.6707 mL	3.3414 mL	16.7068 mL
20 mM	0.1671 mL	0.8353 mL	1.6707 mL	8.3534 mL
50 mM	0.0668 mL	0.3341 mL	0.6683 mL	3.3414 mL
100 mM	0.0334 mL	0.1671 mL	0.3341 mL	1.6707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc