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N-DBCO-N-bis(PEG2-C2-NHS ester)

🥰Excellent
Catalog No. T18410Cas No. 2128735-29-3

N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-like PROTAC linker that can be used to synthesize PROTAC molecules, and also contains a DBCO moiety for click chemistry with azide groups.

N-DBCO-N-bis(PEG2-C2-NHS ester)

N-DBCO-N-bis(PEG2-C2-NHS ester)

🥰Excellent
Catalog No. T18410Cas No. 2128735-29-3
N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-like PROTAC linker that can be used to synthesize PROTAC molecules, and also contains a DBCO moiety for click chemistry with azide groups.
Pack SizePriceAvailabilityQuantity
1 mg$42 In Stock
5 mg$97 In Stock
10 mg$142 In Stock
25 mg$238 In Stock
50 mg$356 In Stock
100 mg$595 In Stock
200 mg$862 In Stock
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Product Introduction

Bioactivity
Description
N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-like PROTAC linker that can be used to synthesize PROTAC molecules, and also contains a DBCO moiety for click chemistry with azide groups.
Chemical Properties
Molecular Weight818.82
FormulaC41H46N4O14
Cas No.2128735-29-3
SmilesO=C(ON1C(=O)CCC1=O)CCOCCOCCN(C(=O)CCC(=O)N2C=3C=CC=CC3C#CC=4C=CC=CC4C2)CCOCCOCCC(=O)ON5C(=O)CCC5=O
Relative Density.1.41 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (48.85 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2213 mL6.1063 mL12.2127 mL61.0635 mL
5 mM0.2443 mL1.2213 mL2.4425 mL12.2127 mL
10 mM0.1221 mL0.6106 mL1.2213 mL6.1063 mL
20 mM0.0611 mL0.3053 mL0.6106 mL3.0532 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

PEGsN-DBCO-N-bis(PEG2-C2-NHS ester)N-DBCO-N-bis(PEG-2-C2-NHS ester)NDBCONbis(PEG2C2NHS ester)N DBCO N bis(PEG2 C2 NHS ester)
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