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N-DBCO-N-bis(PEG2-C2-NHS ester)

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Catalog No. T18410Cas No. 2128735-29-3

N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-like PROTAC linker that can be used to synthesize PROTAC molecules, and also contains a DBCO moiety for click chemistry with azide groups.

N-DBCO-N-bis(PEG2-C2-NHS ester)

N-DBCO-N-bis(PEG2-C2-NHS ester)

🥰Excellent
Catalog No. T18410Cas No. 2128735-29-3
N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-like PROTAC linker that can be used to synthesize PROTAC molecules, and also contains a DBCO moiety for click chemistry with azide groups.
Pack SizePriceAvailabilityQuantity
1 mg$40In Stock
5 mg$92In Stock
10 mg$135In Stock
25 mg$226In Stock
50 mg$338In Stock
100 mg$565In Stock
200 mg$819In Stock
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-like PROTAC linker that can be used to synthesize PROTAC molecules, and also contains a DBCO moiety for click chemistry with azide groups.
Chemical Properties
Molecular Weight818.82
FormulaC41H46N4O14
Cas No.2128735-29-3
SmilesO=C(ON1C(=O)CCC1=O)CCOCCOCCN(C(=O)CCC(=O)N2C=3C=CC=CC3C#CC=4C=CC=CC4C2)CCOCCOCCC(=O)ON5C(=O)CCC5=O
Relative Density.1.41 g/cm3 (Predicted)
ColorYellow
AppearanceViscous
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (48.85 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2213 mL6.1063 mL12.2127 mL61.0635 mL
5 mM0.2443 mL1.2213 mL2.4425 mL12.2127 mL
10 mM0.1221 mL0.6106 mL1.2213 mL6.1063 mL
20 mM0.0611 mL0.3053 mL0.6106 mL3.0532 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PEGsN-DBCO-N-bis(PEG2-C2-NHS ester)N-DBCO-N-bis(PEG-2-C2-NHS ester)NDBCONbis(PEG2C2NHS ester)N DBCO N bis(PEG2 C2 NHS ester)
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