Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 µM, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 µM.[2] Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 µg/ml.[3]
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 μg | 35 days | $ 723.00 | |
100 μg | 35 days | $ 987.00 |
Description | Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 µM, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 µM.[2] Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 µg/ml.[3] |
Molecular Weight | 415.42 |
Formula | C15H21N5O7S |
CAS No. | 143545-90-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: Soluble
DMSO: Soluble
H2O: Soluble
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Cylindrospermopsin 143545-90-8 inhibitor inhibit