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Yakuchinone A

Name: Yakuchinone A
Brand: TargetMol
SKU: T24417
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24417Cas No. 78954-23-1

Alias Yakuchinone-A

Yakuchinone A (Yakuchinone-A) is a natural product isolated from Alpinia oxyphylla Miquel. Yakuchinone-A has strong inhibitory effects on the synthesis of prostaglandins and leukotrienes in vitro. Yakuchinone A inhibits the expression of cyclooxygenase-2 and of inducible nitric oxide synthase (iNOS).

Yakuchinone A

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Purity: 98.48%

Catalog No. T24417Alias Yakuchinone-ACas No. 78954-23-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$129	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$425	In Stock	In Stock
100 mg	$679	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$162	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.48%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR LCMS

Product Introduction

Yakuchinone A AI Summary

Yakuchinone A exhibits cytotoxicity against various human cell lines, including A431, BCC, SCC25, A375, and B16 cells, as indicated by the MTT assay results, which provide IC50 values signifying the concentration required to inhibit cell growth by 50%. Additionally, Yakuchinone A demonstrates significant anti-inflammatory activity, evidenced by its capacity to inhibit ear inflammation in a mouse model of TPA-induced ear edema. It also inhibits 5-LOX in human neutrophils with an IC50 value of 5400.0 nM and COX in bovine seminal vesicles with an IC50 value of 16000.0 nM. Moreover, the compound shows inhibition of prostaglandin biosynthesis in ginger, with an IC50 value of 500.0 nM, suggesting potential anti-inflammatory properties through modulation of various inflammatory pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Yakuchinone A (Yakuchinone-A) is a natural product isolated from Alpinia oxyphylla Miquel. Yakuchinone-A has strong inhibitory effects on the synthesis of prostaglandins and leukotrienes in vitro. Yakuchinone A inhibits the expression of cyclooxygenase-2 and of inducible nitric oxide synthase (iNOS).
Synonyms	Yakuchinone-A

Chemical Properties

Molecular Weight	312.4
Formula	C₂₀H₂₄O₃
Cas No.	78954-23-1
Smiles	C(CC(CCCCC1=CC=CC=C1)=O)C2=CC(OC)=C(O)C=C2
Relative Density.	1.095g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (72.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2010 mL	16.0051 mL	32.0102 mL	160.0512 mL
5 mM	0.6402 mL	3.2010 mL	6.4020 mL	32.0102 mL
10 mM	0.3201 mL	1.6005 mL	3.2010 mL	16.0051 mL
20 mM	0.1601 mL	0.8003 mL	1.6005 mL	8.0026 mL
50 mM	0.0640 mL	0.3201 mL	0.6402 mL	3.2010 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc