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DSPE-SPDP
Catalog No. T77286 Copy Product Info
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DSPE-SPDP is a reactive phospholipid molecule. In aqueous environments, DSPE-SPDP can orient itself to form lipid bilayers or participate in the construction of lipid nanoparticles (LNPs). The SPDP functional group possesses disulfide exchange activity, allowing for the covalent conjugation of sulfhydryl-containing (-SH) biomolecules, such as antibodies, peptides, or siRNAs, to the surface of nanocarriers under physiological conditions.
DSPE-SPDP
Copy Product Info🥰Excellent
Catalog No. T77286
DSPE-SPDP is a reactive phospholipid molecule. In aqueous environments, DSPE-SPDP can orient itself to form lipid bilayers or participate in the construction of lipid nanoparticles (LNPs). The SPDP functional group possesses disulfide exchange activity, allowing for the covalent conjugation of sulfhydryl-containing (-SH) biomolecules, such as antibodies, peptides, or siRNAs, to the surface of nanocarriers under physiological conditions.
Cas No. 144735-79-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $691 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DSPE-SPDP is a reactive phospholipid molecule. In aqueous environments, DSPE-SPDP can orient itself to form lipid bilayers or participate in the construction of lipid nanoparticles (LNPs). The SPDP functional group possesses disulfide exchange activity, allowing for the covalent conjugation of sulfhydryl-containing (-SH) biomolecules, such as antibodies, peptides, or siRNAs, to the surface of nanocarriers under physiological conditions. |
| In vitro | In vitro nanomedicine studies utilize DSPE-SPDP as a functional lipid component. Research demonstrates that nanoscale coordination polymers (NCPs) constructed using DSPE-SPDP can successfully conjugate targeting ligands, facilitating the synergistic delivery of chemotherapeutics and siRNAs in cisplatin-resistant ovarian cancer cell lines, such as OVCAR-3 [1]. |
| In vivo | In vivo, nanocarriers surface-modified with DSPE-SPDP exhibit excellent stability in blood circulation. In animal models bearing cisplatin-resistant ovarian cancer xenografts, this delivery system significantly reduces tumor burden and eradicates resistant tumor lesions through the co-delivery of drugs and genetic materials [1]. |
| Molecular Weight | 945.34 |
| Formula | C49H89N2O9PS2 |
| Cas No. | 144735-79-5 |
| Smiles | [C@@H](COP(OCCNC(CCSSC1=CC=CC=N1)=O)(=O)O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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