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Avenanthramide-C methyl ester

Name: Avenanthramide-C methyl ester
Brand: TargetMol
SKU: T36198
Rating: 4.5 (1 reviews)

Catalog No. T36198 Copy Product Info

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Avenanthramide-C methyl ester inhibits NF-κB activation by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM), thereby dose-dependently inhibiting the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.

Avenanthramide-C methyl ester

Copy Product Info

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Catalog No. T36198

Cas No. 955382-52-2

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Pack Size	Price	USA Stock	Global Stock
500 μg	$138	35 days	35 days
1 mg	$253	35 days	35 days
5 mg	$1,050	35 days	35 days
10 mg	$1,830	35 days	35 days

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	329.3
Formula	C₁₇H₁₅NO₆
Cas No.	955382-52-2
Smiles	C(OC)(=O)C1=C(NC(/C=C/C2=CC(O)=C(O)C=C2)=O)C=CC(O)=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL (1.52 mM), Sonication is recommended.

DMSO: 20 mg/mL (60.73 mM), Sonication is recommended.

DMF: 20 mg/mL (60.73 mM), Sonication is recommended.

Ethanol: 10 mg/mL (30.37 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO/DMF

	1mg	5mg	10mg	50mg
5 mM	0.6073 mL	3.0367 mL	6.0735 mL	30.3674 mL
10 mM	0.3037 mL	1.5184 mL	3.0367 mL	15.1837 mL
20 mM	0.1518 mL	0.7592 mL	1.5184 mL	7.5919 mL

DMSO/DMF

	1mg	5mg	10mg	50mg
50 mM	0.0607 mL	0.3037 mL	0.6073 mL	3.0367 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc