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DL-AP7

Name: DL-AP7
Brand: TargetMol
SKU: T22734
Rating: 4.5 (1 reviews)

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Catalog No. T22734Cas No. 85797-13-3

DL-AP7, a competitive NMDA antagonist and anticonvulsant, blocks NMDA-induced convulsions and impairs learning performance in mice during a passive avoidance task [1].

DL-AP7

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Catalog No. T22734Cas No. 85797-13-3

DL-AP7, a competitive NMDA antagonist and anticonvulsant, blocks NMDA-induced convulsions and impairs learning performance in mice during a passive avoidance task [1].

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	4-6 weeks	4-6 weeks
50 mg	$1,980	4-6 weeks	4-6 weeks
100 mg	$2,500	4-6 weeks	4-6 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	DL-AP7, a competitive NMDA antagonist and anticonvulsant, blocks NMDA-induced convulsions and impairs learning performance in mice during a passive avoidance task [1].
In vivo	DL-AP7, when administered intracerebroventricularly (ICV), inhibits convulsions triggered by NMDA with an effective dose (ED 50) of 0.22 nmol/mouse. Additionally, it detrimentally affects the ability of mice to learn in a passive avoidance task [1].

Chemical Properties

Molecular Weight	225.18
Formula	C₇H₁₆NO₅P
Cas No.	85797-13-3
Smiles	NC(CCCCCP(O)(O)=O)C(O)=O
Relative Density.	1.39 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1eq. NaOH: 100 mM, Sonication is recommended.

Solution Preparation Table

1eq. NaOH

	1mg	5mg	10mg	50mg
1 mM	4.4409 mL	22.2045 mL	44.4089 mL	222.0446 mL
5 mM	0.8882 mL	4.4409 mL	8.8818 mL	44.4089 mL
10 mM	0.4441 mL	2.2204 mL	4.4409 mL	22.2045 mL
20 mM	0.2220 mL	1.1102 mL	2.2204 mL	11.1022 mL
50 mM	0.0888 mL	0.4441 mL	0.8882 mL	4.4409 mL
100 mM	0.0444 mL	0.2220 mL	0.4441 mL	2.2204 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc