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(E)-Naringenin chalcone

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Catalog No. T2S2173Cas No. 73692-50-9
Alias trans-2'4'6'4-tetrahydroxychalcone, Isosalipurpol, Chalconaringenin

Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid that improves adipocyte metabolic functions and exerts insulin-sensitizing effects by activating an adiponectin-related pathway. Naringenin chalcone exhibits anti-inflammatory properties by inhibiting the production of proinflammatory cytokines in the interaction between adipocytes and macrophages, may be useful for ameliorating the inflammatory changes in obese adipose tissue.

(E)-Naringenin chalcone
Other Forms of (E)-Naringenin chalcone:
Naringenin chalconeT778425515-46-2
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(E)-Naringenin chalcone

😃Good
Purity: 98.74%
Catalog No. T2S2173Alias trans-2'4'6'4-tetrahydroxychalcone, Isosalipurpol, ChalconaringeninCas No. 73692-50-9
Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid that improves adipocyte metabolic functions and exerts insulin-sensitizing effects by activating an adiponectin-related pathway. Naringenin chalcone exhibits anti-inflammatory properties by inhibiting the production of proinflammatory cytokines in the interaction between adipocytes and macrophages, may be useful for ameliorating the inflammatory changes in obese adipose tissue.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39In StockIn Stock
5 mg$80In StockIn Stock
10 mg$123In StockIn Stock
25 mg$215In StockIn Stock
50 mg$322-In Stock
1 mL x 10 mM (in DMSO)$82BackorderBackorder
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.74%
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Product Introduction

Bioactivity
Description
Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid that improves adipocyte metabolic functions and exerts insulin-sensitizing effects by activating an adiponectin-related pathway. Naringenin chalcone exhibits anti-inflammatory properties by inhibiting the production of proinflammatory cytokines in the interaction between adipocytes and macrophages, may be useful for ameliorating the inflammatory changes in obese adipose tissue.
Synonymstrans-2'4'6'4-tetrahydroxychalcone, Isosalipurpol, Chalconaringenin
Chemical Properties
Molecular Weight272.25
FormulaC15H12O5
Cas No.73692-50-9
SmilesOc1ccc(\C=C\C(=O)c2c(O)cc(O)cc2O)cc1
Relative Density.1.483g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 49 mg/mL (179.98 mM), Sonication is recommended.
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.35 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6731 mL18.3655 mL36.7309 mL183.6547 mL
5 mM0.7346 mL3.6731 mL7.3462 mL36.7309 mL
10 mM0.3673 mL1.8365 mL3.6731 mL18.3655 mL
20 mM0.1837 mL0.9183 mL1.8365 mL9.1827 mL
50 mM0.0735 mL0.3673 mL0.7346 mL3.6731 mL
100 mM0.0367 mL0.1837 mL0.3673 mL1.8365 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

skinNaringenin chalconemetabolitesInhibitorinhibitInflammatoryflavonoidsdisordersallergic2′,4,4′,6′-Tetrahydroxychalcone2′,4,4′,6′Tetrahydroxychalcone2′,4,4′,6′ Tetrahydroxychalcone
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