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DACN(Tos2,6-OH)
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Catalog No. T87926Cas No. 2109751-74-6
DACN(Tos2,6-OH) serves as a potent click chemistry reagent featuring an Azide group and a distinctively bent alkyne moiety. This structure enhances its reactivity for cycloaddition reactions compared to nonbent acyclic alkynes, especially evident in cyclononyne alkynes which exhibit substantially higher reactivity. The bent configuration adds both electronic and steric effects that intensify the reactivity, facilitating strain-promoted azide-alkyne cycloaddition (SPAAC). SPAAC with cycloalkynes is commonly utilized for dependable molecular conjugation across various fields. Furthermore, DACN(Tos2,6-OH) can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), coupling efficiently with molecules that contain Azide groups. Compared to cyclooctynes, DACNs demonstrate superior thermal and chemical stabilities while maintaining similar click reactivity [1]. Nitrogens within the compound provide versatile linking sites for numerous functional units.
DACN(Tos2,6-OH)
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Catalog No. T87926Cas No. 2109751-74-6
DACN(Tos2,6-OH) serves as a potent click chemistry reagent featuring an Azide group and a distinctively bent alkyne moiety. This structure enhances its reactivity for cycloaddition reactions compared to nonbent acyclic alkynes, especially evident in cyclononyne alkynes which exhibit substantially higher reactivity. The bent configuration adds both electronic and steric effects that intensify the reactivity, facilitating strain-promoted azide-alkyne cycloaddition (SPAAC). SPAAC with cycloalkynes is commonly utilized for dependable molecular conjugation across various fields. Furthermore, DACN(Tos2,6-OH) can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), coupling efficiently with molecules that contain Azide groups. Compared to cyclooctynes, DACNs demonstrate superior thermal and chemical stabilities while maintaining similar click reactivity [1]. Nitrogens within the compound provide versatile linking sites for numerous functional units.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Storage & Solubility Information
| Description | DACN(Tos2,6-OH) serves as a potent click chemistry reagent featuring an Azide group and a distinctively bent alkyne moiety. This structure enhances its reactivity for cycloaddition reactions compared to nonbent acyclic alkynes, especially evident in cyclononyne alkynes which exhibit substantially higher reactivity. The bent configuration adds both electronic and steric effects that intensify the reactivity, facilitating strain-promoted azide-alkyne cycloaddition (SPAAC). SPAAC with cycloalkynes is commonly utilized for dependable molecular conjugation across various fields. Furthermore, DACN(Tos2,6-OH) can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), coupling efficiently with molecules that contain Azide groups. Compared to cyclooctynes, DACNs demonstrate superior thermal and chemical stabilities while maintaining similar click reactivity [1]. Nitrogens within the compound provide versatile linking sites for numerous functional units. |
| Molecular Weight | 448.56 |
| Formula | C21H24N2O5S2 |
| Cas No. | 2109751-74-6 |
| Smiles | S(=O)(=O)(C1=CC=C(C)C=C1)N2CC(O)CN(S(=O)(=O)C3=CC=C(C)C=C3)CC#CC2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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