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BBO-8520

🥰Excellent
Catalog No. T85809Cas No. 2893809-51-1
Alias BBO8520

BBO-8520 is a first-in-class, direct dual inhibitor of both the active (ON) and inactive (OFF) conformational states of KRASG12C. BBO-8520 binds to the Switch-II/Helix3 pocket of KRASG12C, covalently modifying the target cysteine residue and thereby disabling effector binding in the ON state. BBO-8520 exhibits potent inhibition of KRAS signaling under growth factor-activated conditions, where existing OFF-only inhibitors demonstrate minimal activity. In vivo, BBO-8520 rapidly engages its target and suppresses signaling, resulting in durable tumor regression across multiple models, including those resistant to OFF-only KRASG12C inhibitors.

BBO-8520

BBO-8520

🥰Excellent
Purity: 97.879%
Catalog No. T85809Alias BBO8520Cas No. 2893809-51-1
BBO-8520 is a first-in-class, direct dual inhibitor of both the active (ON) and inactive (OFF) conformational states of KRASG12C. BBO-8520 binds to the Switch-II/Helix3 pocket of KRASG12C, covalently modifying the target cysteine residue and thereby disabling effector binding in the ON state. BBO-8520 exhibits potent inhibition of KRAS signaling under growth factor-activated conditions, where existing OFF-only inhibitors demonstrate minimal activity. In vivo, BBO-8520 rapidly engages its target and suppresses signaling, resulting in durable tumor regression across multiple models, including those resistant to OFF-only KRASG12C inhibitors.
Pack SizePriceAvailabilityQuantity
1 mg$424In Stock
5 mg$1,060In Stock
10 mg$1,700In Stock
25 mg$3,400In Stock
1 mL x 10 mM (in DMSO)$1,700In Stock
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Purity:97.879%
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Product Introduction

Bioactivity
Description
BBO-8520 is a first-in-class, direct dual inhibitor of both the active (ON) and inactive (OFF) conformational states of KRASG12C. BBO-8520 binds to the Switch-II/Helix3 pocket of KRASG12C, covalently modifying the target cysteine residue and thereby disabling effector binding in the ON state. BBO-8520 exhibits potent inhibition of KRAS signaling under growth factor-activated conditions, where existing OFF-only inhibitors demonstrate minimal activity. In vivo, BBO-8520 rapidly engages its target and suppresses signaling, resulting in durable tumor regression across multiple models, including those resistant to OFF-only KRASG12C inhibitors.
In vivo
BBO-8520 (10 mg/kg/d; po) inhibits pERK and KRAS G12C activation in the KrasG12C-p53 driven GEMM model, resulting in sustained tumor regression. Additionally, BBO-8520 demonstrates a strong dose- and time-dependent pharmacodynamic effect in KRASG12C mutant tumor-bearing mice, with pERK inhibition exceeding 80% [1].
SynonymsBBO8520
Chemical Properties
Molecular Weight729.74
FormulaC35H33F6N7O2S
Cas No.2893809-51-1
SmilesN#CC1=C(SC2=C(F)C=CC(=C12)C=3C(F)=C4N=C(N=C(C4=CC3C(F)(F)F)N5CC(N(C(=O)C=C)CC5C)C)OCC67N(CCC6)CC(F)C7)N
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: ≥ 40 mg/mL, Sonication is recommended.

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