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Neuropeptide W-30 (rat)

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Catalog No. TP2611Cas No. 383415-90-5
Alias NPW30, rat

Neuropeptide W-30 (rat) acts as a crucial stress mediator within the central nervous system, influencing the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. It serves as an endogenous ligand for the two related orphan G-protein-coupled receptors (GPCRs), GPR7 and GPR8. NPW-30 binds and activates both GPR7 and GPR8 at comparable effective doses [1] [2] [3].

Neuropeptide W-30 (rat)

Neuropeptide W-30 (rat)

😃Good
Catalog No. TP2611Alias NPW30, ratCas No. 383415-90-5
Neuropeptide W-30 (rat) acts as a crucial stress mediator within the central nervous system, influencing the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. It serves as an endogenous ligand for the two related orphan G-protein-coupled receptors (GPCRs), GPR7 and GPR8. NPW-30 binds and activates both GPR7 and GPR8 at comparable effective doses [1] [2] [3].
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Bioactivity
Description
Neuropeptide W-30 (rat) acts as a crucial stress mediator within the central nervous system, influencing the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. It serves as an endogenous ligand for the two related orphan G-protein-coupled receptors (GPCRs), GPR7 and GPR8. NPW-30 binds and activates both GPR7 and GPR8 at comparable effective doses [1] [2] [3].
In vitro
Neuropeptide W-30 (i.c.v.) alters the secretion of anterior pituitary hormones, such as prolactin and growth hormone, and affects behaviors like feeding and drinking.
SynonymsNPW30, rat
Chemical Properties
Molecular Weight3559.11
FormulaC165H249N49O38S
Cas No.383415-90-5
SmilesC([C@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC(=O)[C@H]4N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC5=CN=CN5)NC([C@@H](NC([C@H](CC6=CC=C(O)C=C6)NC([C@H](CC=7C=8C(NC7)=CC=CC8)N)=O)=O)CCCCN)=O)=O)C(C)C)=O)C)=O)CO)=O)CCC4)CCCNC(=N)N)=O)=O)=O)[C@@H](C)O)=O)[C@H](C)C)=O)=O)CCCNC(=N)N)=O)C)=O)CO)=O)=O)CC(C)C)=O)CC(C)C)=O)CCSC)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CO)=O)CCC1)CC9=CC=C(O)C=C9)=O)CC(C)C)=O)C(O)=O)C=%10C=%11C(NC%10)=CC=CC%11
SequenceTrp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ser-Gly-Leu-Leu-Met-Gly-Leu-Arg-Arg-Ser-Pro-Tyr-Leu-Trp
Sequence ShortWYKHVASPRYHTVGRASGLLMGLRRSPYLW
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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