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RGB-286638

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Catalog No. T73196Cas No. 784210-87-3

RGB-286638 is a multi-target CDK inhibitor that effectively hampers the kinase activity of a range of cyclin-CDK complexes, including cyclin T1-CDK9 (IC50 = 1 nM), cyclin B1-CDK1 (IC50 = 2 nM), cyclin E-CDK2 (IC50 = 3 nM), cyclin D1-CDK4 (IC50 = 4 nM), cyclin E-CDK3 (IC50 = 5 nM), and p35-CDK5 (IC50 = 5 nM). Additionally, it inhibits other kinases such as GSK-3β (IC50 = 3 nM), TAK1 (IC50 = 5 nM), Jak2 (IC50 = 50 nM), and MEK1 (IC50 = 54 nM), showcasing its versatile inhibitory potential.

RGB-286638
Other Forms of RGB-286638:
RGB-286638 free baseT2378784210-88-4
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RGB-286638

😃Good
Catalog No. T73196Cas No. 784210-87-3
RGB-286638 is a multi-target CDK inhibitor that effectively hampers the kinase activity of a range of cyclin-CDK complexes, including cyclin T1-CDK9 (IC50 = 1 nM), cyclin B1-CDK1 (IC50 = 2 nM), cyclin E-CDK2 (IC50 = 3 nM), cyclin D1-CDK4 (IC50 = 4 nM), cyclin E-CDK3 (IC50 = 5 nM), and p35-CDK5 (IC50 = 5 nM). Additionally, it inhibits other kinases such as GSK-3β (IC50 = 3 nM), TAK1 (IC50 = 5 nM), Jak2 (IC50 = 50 nM), and MEK1 (IC50 = 54 nM), showcasing its versatile inhibitory potential.
Pack SizePriceAvailabilityQuantity
25 mg$766 10-14 weeks
50 mg$996 10-14 weeks
100 mg$1,990 10-14 weeks
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Product Introduction

Bioactivity
Description
RGB-286638 is a multi-target CDK inhibitor that effectively hampers the kinase activity of a range of cyclin-CDK complexes, including cyclin T1-CDK9 (IC50 = 1 nM), cyclin B1-CDK1 (IC50 = 2 nM), cyclin E-CDK2 (IC50 = 3 nM), cyclin D1-CDK4 (IC50 = 4 nM), cyclin E-CDK3 (IC50 = 5 nM), and p35-CDK5 (IC50 = 5 nM). Additionally, it inhibits other kinases such as GSK-3β (IC50 = 3 nM), TAK1 (IC50 = 5 nM), Jak2 (IC50 = 50 nM), and MEK1 (IC50 = 54 nM), showcasing its versatile inhibitory potential.
Targets&IC50
JNK1a2:40 nM, Cyclin E-CDK2:3 nM, CDK9-CyclinT1:1 nM, CDK6-CyclinD3:55 nM, JNK1a1:17 nM, AMPK:41 nM, Cyclin E-CDK3:5 nM, Cyclin D1-CDK4:4 nM, GSK-3β:3 nM, c-Src:25 nM, CDK7-CyclinH:44 nM, MEK1:54 nM, FMS:1 nM, TAK1:5 nM, Cyclin B1-CDK1:2 nM, JAK2:50 nM, CDK5-p35:5 nM
Chemical Properties
Molecular Weight618.55
FormulaC29H37Cl2N7O4
Cas No.784210-87-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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