Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal activity in cancer studies, H3B-968 specifically inhibits WRN's helicase function through competitive ATP antagonism [1].
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Description | H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal activity in cancer studies, H3B-968 specifically inhibits WRN's helicase function through competitive ATP antagonism [1]. |
Molecular Weight | 548.46 |
Formula | C22H18F6N4O4S |
CAS No. | 2912294-90-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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H3B-968 2912294-90-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor inhibit