Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIMR3030, a potent inhibitor of SARS-CoV-2 PLpro, possesses an IC50 of 0.0399 µg/mL and demonstrates antiviral activity by diminishing the expression of SARS-CoV spike, ORF1b, IFN-α, and IL-6 mRNA. Additionally, SIMR3030 has been shown to have a satisfactory safety profile in mice [1].
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Description | SIMR3030, a potent inhibitor of SARS-CoV-2 PLpro, possesses an IC50 of 0.0399 µg/mL and demonstrates antiviral activity by diminishing the expression of SARS-CoV spike, ORF1b, IFN-α, and IL-6 mRNA. Additionally, SIMR3030 has been shown to have a satisfactory safety profile in mice [1]. |
In vitro | SIMR3030 (0-100 µg/mL) exhibits antiviral activity with IC50 values against SARS-CoV-2 and MERS-CoV of 12.1 and 6.206 µg/mL, respectively [1]. At a concentration of 20 µg/mL and exposure times of 1, 6, and 12 hours, SIMR3030 reduces the expression levels of SARS-CoV spike, ORF1b, IFN-α, and IL-6 mRNA in Caco-2 cells [1]. |
In vivo | SIMR3030 (25, 50, 100 mg/kg; i.p.; once daily for 14 days) demonstrated good safety profiles in an experimental mouse model [1]. |
Molecular Weight | 427.54 |
Formula | C27H29N3O2 |
CAS No. | 2708270-99-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SIMR3030 2708270-99-7 Microbiology/Virology SARS-CoV inhibitor inhibit