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Cyclo(his-pro) TFA
(Synonyms: Histidylproline diketopiperazine TFA, Cyclohistidyl-proline TFA, Cyclohistidyl proline TFA) Copy Product Info
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Synonyms: Histidylproline diketopiperazine TFA, Cyclohistidyl-proline TFA, Cyclohistidyl proline TFA
Catalog No. T61171 Copy Product Info
Purity: 99.94%
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Cyclo(his-pro) TFA, an orally active cyclic dipeptide structurally related to thyrotropin-releasing hormone, demonstrates inhibitory effects on NF-κB nuclear accumulation. Cyclo(his-pro) TFA additionally possesses the capacity to cross the blood-brain barrier and modulate multiple inflammatory and stress-associated responses. Cyclo(his-pro) TFA is therefore applicable to neuroinflammation, neuroendocrine regulation, and central nervous system signaling investigations.
Cas No. 936749-56-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $32 | - | In Stock | |
| 5 mg | $73 | - | In Stock | |
| 10 mg | $118 | - | In Stock | |
| 25 mg | $196 | - | In Stock | |
| 50 mg | $292 | - | In Stock | |
| 100 mg | $433 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $80 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.94%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cyclo(his-pro) TFA, an orally active cyclic dipeptide structurally related to thyrotropin-releasing hormone, demonstrates inhibitory effects on NF-κB nuclear accumulation. Cyclo(his-pro) TFA additionally possesses the capacity to cross the blood-brain barrier and modulate multiple inflammatory and stress-associated responses. Cyclo(his-pro) TFA is therefore applicable to neuroinflammation, neuroendocrine regulation, and central nervous system signaling investigations. |
| In vitro | Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA; 50 μM; 1–48 h) increases Nrf2 levels in the nucleus and inhibits NF-κB nuclear translocation, whereas Cyclo(His-Pro) alone does not affect the nuclear translocation of these transcription factors[1]. Cyclo(his-pro) TFA (50 μM; administered prior to 48 h paraquat exposure) prevents protein nitration induced by paraquat (PQ) and mitigates its functional consequences, as evidenced by reduced cell apoptosis measured through caspase-3 activity and cytochrome c release[1]. Cyclo(his-pro) TFA suppresses NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 signaling pathway[1]. |
| In vivo | Cyclo(his-pro) TFA (1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear edema, confirming its anti-inflammatory activity[1]. |
| Synonyms | Histidylproline diketopiperazine TFA, Cyclohistidyl-proline TFA, Cyclohistidyl proline TFA |
| Molecular Weight | 348.28 |
| Formula | C13H15F3N4O4 |
| Cas No. | 936749-56-3 |
| Smiles | C(C(O)=O)(F)(F)F.O=C1N2[C@](C(=O)N[C@H]1CC3=CN=CN3)(CCC2)[H] |
| Sequence | Cyclo(His-Pro) |
| Sequence Short | Cyclo(HP) |
| Storage | Store under nitrogen,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 208 mg/mL (597.22 mM), Sonication is recommended. H2O: 100 mg/mL (287.13 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Cyclo(his-pro) TFA chemical structure | Cyclo(his-pro) TFA in vivo | Cyclo(his-pro) TFA in vitro | Cyclo(his-pro) TFA formula | Cyclo(his-pro) TFA molecular weight
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