DALDA TFA

Name: DALDA TFA
Brand: TargetMol
SKU: T80086
Rating: 4.5 (1 reviews)

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Catalog No. T80086

DALDA TFA is a potent, μ-opioid receptor agonist exhibiting high selectivity and an affinity constant (K i) of 1.69 nM. It demonstrates antinociceptive properties and influences respiratory functions [1].

DALDA TFA

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Catalog No. T80086

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	DALDA TFA is a potent, μ-opioid receptor agonist exhibiting high selectivity and an affinity constant (K i) of 1.69 nM. It demonstrates antinociceptive properties and influences respiratory functions [1].
In vitro	DALDA possesses a net positive charge of 3+ at physiological pH, making it hydrophilic and increasing its polarity relative to morphine [1].
In vivo	DALDA administered intrathecally at doses ranging from 0 to 7 nmol/rat exhibits both antinociceptive and respiratory effects in rats [1]. When delivered intracerebroventricularly at 0.1 and 1.0 μg/side, DALDA induces a biphasic response characterized by initial suppression, then pronounced inhibition, and subsequent activation of horizontal movement, rearing, and stereotypy behaviors in rats [2].

Chemical Properties

Molecular Weight	611.74 (free base)
Formula	C₃₀H₄₅N₉O₅.xC₂HF₃O₂
Sequence	Tyr-{d-Arg}-Phe-Lys-NH2
Sequence Short	Y-{d-Arg}-FK

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc