hCAIX-IN-15

Name: hCAIX-IN-15
Brand: TargetMol
SKU: T73029
Rating: 4.5 (1 reviews)

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Catalog No. T73029Cas No. 2849348-43-0

hCAIX-IN-15, a potent inhibitor of human carbonic anhydrase IX (hCA IX), has an inhibition constant (Ki) of 38.8 nM and exhibits broad-spectrum anticancer activity suitable for cancer research [1].

hCAIX-IN-15

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Catalog No. T73029Cas No. 2849348-43-0

hCAIX-IN-15, a potent inhibitor of human carbonic anhydrase IX (hCA IX), has an inhibition constant (Ki) of 38.8 nM and exhibits broad-spectrum anticancer activity suitable for cancer research [1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	8-10 weeks	8-10 weeks
50 mg	Inquiry	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	hCAIX-IN-15, a potent inhibitor of human carbonic anhydrase IX (hCA IX), has an inhibition constant (Ki) of 38.8 nM and exhibits broad-spectrum anticancer activity suitable for cancer research [1].
Targets&IC50	CA IX (human):38.8 nM (Ki)
In vitro	Compound 12i, designated as hCAIX-IN-15, exhibits potent cytotoxic effects after a 48-hour exposure on renal cancer (UO-31), breast cancer (MDA-MB-468), and non-small cell lung cancer (HOP-92) cell lines, with growth inhibition (GI%) values of 20%, 17%, and 16%, respectively [1].

Chemical Properties

Molecular Weight	411.41
Formula	C₁₈H₁₄FN₇O₂S
Cas No.	2849348-43-0
Smiles	#N/A

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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