Powder: -20°C for 3 years | In solvent: -80°C for 1 year
hCAIX-IN-15 is a potent inhibitor of human carbonic anhydrase IX (hCA IX) with an inhibition constant (Ki) of 38.8 nM, exhibiting broad-spectrum anticancer activity suitable for cancer research [1].
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Description | hCAIX-IN-15 is a potent inhibitor of human carbonic anhydrase IX (hCA IX) with an inhibition constant (Ki) of 38.8 nM, exhibiting broad-spectrum anticancer activity suitable for cancer research [1]. |
Targets&IC50 | hCA IX:38.8 nM (Ki) |
In vitro | Compound 12i, designated as hCAIX-IN-15, exhibits potent cytotoxic effects after a 48-hour exposure on renal cancer (UO-31), breast cancer (MDA-MB-468), and non-small cell lung cancer (HOP-92) cell lines, with growth inhibition (GI%) values of 20%, 17%, and 16%, respectively [1]. |
Molecular Weight | 411.41 |
Formula | C18H14FN7O2S |
CAS No. | 2849348-43-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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hCAIX-IN-15 2849348-43-0 Metabolism Carbonic Anhydrase inhibitor inhibit