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4-Methylesculetin

Name: 4-Methylesculetin
Brand: TargetMol
SKU: TJS0338
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TJS0338Cas No. 529-84-0

Alias Methylesculetin, 4-Methyl-6,7-dihydroxycoumarin

4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.

4-Methylesculetin

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Purity: 97.96%

Catalog No. TJS0338Alias Methylesculetin, 4-Methyl-6,7-dihydroxycoumarinCas No. 529-84-0

4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	In Stock	In Stock
500 mg	$92	-	In Stock
1 g	$133	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.96%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

4-Methylesculetin AI Summary

4-Methylesculetin exhibits diverse bioactivities against a variety of targets. It binds to FK506 binding protein (FKBP) with a dissociation constant (Kd) of 1500000 nM and inhibits xanthine oxidase with an IC50 value of 246000 nM. It is also an inhibitor of aldose reductase enzymes (aldose reductase 1 and 2) and sorbitol dehydrogenase, with the most potent inhibition seen towards kidney aldose reductase 2 (IC50 of 38300 nM). Additionally, 4-Methylesculetin inhibits alpha-glucosidase (IC50 of 94250 nM), is cytotoxic against human U937 cells (CC50 of 76000 nM), and demonstrates antiproliferative activity against these cells (IC50 of 97400 nM). The compound inhibits the interaction of the Thyroid Hormone Receptor with Steroid Receptor Coregulator 2, and shows activity against HSD17B4, JMJD2E, Cruzain, ALDH1A1, and HPGD. It can activate Cytochrome P450 3A4 and exhibits antiviral activity against SARS-CoV-2 (IC50 > 20000 nM). Additionally, it significantly inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells and shows activity in displacing the FAM-Bid peptide from recombinant His6x-tagged human Mcl-1 (Ki of 1190 nM and IC50 of 6280 nM). Finally, it is involved in High Throughput Screening for Foot and Mouth Disease Virus antivirals and induces erasure of genomic imprints..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.
Synonyms	Methylesculetin, 4-Methyl-6,7-dihydroxycoumarin

Chemical Properties

Molecular Weight	192.17
Formula	C₁₀H₈O₄
Cas No.	529-84-0
Smiles	CC1=CC(=O)OC2=CC(O)=C(O)C=C12
Relative Density.	1.0825 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 45 mg/mL (234.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2037 mL	26.0186 mL	52.0373 mL	260.1863 mL
5 mM	1.0407 mL	5.2037 mL	10.4075 mL	52.0373 mL
10 mM	0.5204 mL	2.6019 mL	5.2037 mL	26.0186 mL
20 mM	0.2602 mL	1.3009 mL	2.6019 mL	13.0093 mL
50 mM	0.1041 mL	0.5204 mL	1.0407 mL	5.2037 mL
100 mM	0.0520 mL	0.2602 mL	0.5204 mL	2.6019 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc