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Tos-PEG3

Name: Tos-PEG3
Brand: TargetMol
SKU: T17129
Rating: 4.5 (1 reviews)

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Catalog No. T17129Cas No. 77544-68-4

Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].

Tos-PEG3

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Catalog No. T17129Cas No. 77544-68-4

Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	7-10 days	7-10 days
500 mg	Inquiry	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].
In vitro	PROTACs consist of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other to the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical Properties

Molecular Weight	304.36
Formula	C₁₃H₂₀O₆S
Cas No.	77544-68-4
Smiles	S(OCCOCCOCCO)(=O)(=O)C1=CC=C(C)C=C1
Relative Density.	1.234 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (328.56 mM), Sonication and heating are recommended.

H2O: 10 mg/mL (32.86 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2856 mL	16.4279 mL	32.8558 mL	164.2791 mL
5 mM	0.6571 mL	3.2856 mL	6.5712 mL	32.8558 mL
10 mM	0.3286 mL	1.6428 mL	3.2856 mL	16.4279 mL
20 mM	0.1643 mL	0.8214 mL	1.6428 mL	8.2140 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0657 mL	0.3286 mL	0.6571 mL	3.2856 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6428 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc