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NNC 05-2090
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Catalog No. T28183Cas No. 184845-43-0
Alias NNC05-2090, NNC-05-2090, NNC-052090, NNC052090, NNC 052090
NNC 05-2090 is a GABA uptake inhibitor that exhibits moderate selectivity for BGT-1 transporters over other GABA transporter subtypes, while also displaying measurable affinity toward α1-adrenergic and D2-dopaminergic receptors, making NNC 05-2090 a multifunctional neuropharmacological tool for investigating inhibitory neurotransmission and transporter-receptor cross-regulation.
NNC 05-2090
😃Good
Catalog No. T28183Alias NNC05-2090, NNC-05-2090, NNC-052090, NNC052090, NNC 052090Cas No. 184845-43-0
NNC 05-2090 is a GABA uptake inhibitor that exhibits moderate selectivity for BGT-1 transporters over other GABA transporter subtypes, while also displaying measurable affinity toward α1-adrenergic and D2-dopaminergic receptors, making NNC 05-2090 a multifunctional neuropharmacological tool for investigating inhibitory neurotransmission and transporter-receptor cross-regulation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | 6-8 weeks | 6-8 weeks | |
| 5 mg | $722 | 6-8 weeks | 6-8 weeks | |
| 10 mg | $987 | 6-8 weeks | 6-8 weeks | |
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | NNC 05-2090 is a GABA uptake inhibitor that exhibits moderate selectivity for BGT-1 transporters over other GABA transporter subtypes, while also displaying measurable affinity toward α1-adrenergic and D2-dopaminergic receptors, making NNC 05-2090 a multifunctional neuropharmacological tool for investigating inhibitory neurotransmission and transporter-receptor cross-regulation. |
| In vitro | In rat synaptosomes, NNC 05-2090 inhibited GABA uptake with IC50 values of 4.4 μM (cortical) and 2.5 μM (collicular). Selectivity assays showed inhibition of GAT-1, GAT-2, and GAT-3 (IC50 22-45 μM), along with affinity for monoamine transporters (IC50 4-8 μM) and α1-adrenoceptors (IC50 266 nM) [1]. |
| In vivo | In DBA/2 mice, intraperitoneal (i.p.) administration of NNC 05-2090 inhibits sound-induced tonic and clonic convulsions with ED50 values of 19 umol/kg and 26 umol/kg. In the Maximal Electroshock (MES) test, it antagonizes tonic hindlimb extension with an ED50 of 73 umol/kg. In amygdala-kindled rats, doses of 72-242 umol/kg reduce the severity of generalized seizures and shorten after-discharge duration. The compound also reverses mechanical allodynia in models of partial sciatic nerve ligation [1][2]. |
| Synonyms | NNC05-2090, NNC-05-2090, NNC-052090, NNC052090, NNC 052090 |
| Molecular Weight | 414.54 |
| Formula | C27H30N2O2 |
| Cas No. | 184845-43-0 |
| Smiles | OC1(C=2C=CC=CC2OC)CCN(CCCN3C=4C=CC=CC4C=5C=CC=CC53)CC1 |
| Relative Density. | 1.17 g/cm3 (Predicted) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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