Claudin-6 Protein, Human, Recombinant, Fluorescent,VLP

Claudin-6 (CLDN6) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and intracellular N and C tails. CLDN6 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It regulates the paracellular flux of cations in the kidney through forming heterotypic strands with other claudins and has a role in maintaining the lung epithelial barrier function. The CLDN6 gene is adjacent to another family member, CLDN9, on chromosome 16. Certain CLDN6-positive cancers, encompassing ovarian, endometrial, and testicular malignancies, have been shown to have their proliferation and invasiveness suppressed upon CLDN6 silencing.

Pack Size	Availability	Price/USD
20 μg	5 days	$ 838.00
100 μg	5 days	$ 1,670.00
500 μg	5 days	$ 5,310.00

Pack Size

Availability

Price/USD

Quantity

20 μg

5 days

$ 838.00

100 μg

5 days

$ 1,670.00

500 μg

5 days

$ 5,310.00

Description

Species	Human
Expression System	HEK293
Tag	Tag Free
Accession Number	P56747
Synonyms	claudin 6
Construction	A DNA sequence encoding the human CLDN6 (P56747) (Met1-Val220) was expressed. This protein carries a GFP tag.
Molecular Weight	50.31 kDa (predicted)

Endotoxin	< 1.0 EU per μg protein as determined by the LAL method.
Formulation	Supplied as solution in 50mM HEPES, 150mM NaCI, 10% Trehalose, pH 7.2. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	It is supplied and shipped as Solution with dry ice.
Research Background	Claudin-6 (CLDN6) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and intracellular N and C tails. CLDN6 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It regulates the paracellular flux of cations in the kidney through forming heterotypic strands with other claudins and has a role in maintaining the lung epithelial barrier function. The CLDN6 gene is adjacent to another family member, CLDN9, on chromosome 16. Certain CLDN6-positive cancers, encompassing ovarian, endometrial, and testicular malignancies, have been shown to have their proliferation and invasiveness suppressed upon CLDN6 silencing.