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NHC-diphosphate

Name: NHC-diphosphate
Brand: TargetMol
SKU: T36880
Rating: 4.5 (1 reviews)

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Catalog No. T36880Cas No. 39023-73-9

NHC-diphosphate, a phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in its diphosphate form[1], serves as a potent antiviral agent. As a pyrimidine ribonucleoside, NHC effectively counters the replication of Venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV), and hepatitis C virus (HCV)[1].

NHC-diphosphate

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Catalog No. T36880Cas No. 39023-73-9

Pack Size	Price	Availability
1 mg	$315	Backorder
5 mg	$664	Backorder
10 mg	$995	Backorder

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Product Introduction

Bioactivity

Description	NHC-diphosphate, a phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in its diphosphate form[1], serves as a potent antiviral agent. As a pyrimidine ribonucleoside, NHC effectively counters the replication of Venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV), and hepatitis C virus (HCV)[1].
In vitro	Huh-7 cells were exposed to (10-50 μM; 4 h) either NHC or a McGuigan phosphoramidate prodrug of NHC. Subsequent analysis of intracellular levels of these compounds and their phosphorylated derivatives was performed using LC-MS/MS. The analysis revealed the presence of modest concentrations of NHC-monophosphate (MP) and NHC-diphosphate, with NHC-triphosphate being the predominant metabolite.[1].

Chemical Properties

Molecular Weight	419.18
Formula	C₉H₁₅N₃O₁₂P₂
Cas No.	39023-73-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 160 mg/mL (381.7 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.3856 mL	11.9281 mL	23.8561 mL	119.2805 mL
5 mM	0.4771 mL	2.3856 mL	4.7712 mL	23.8561 mL
10 mM	0.2386 mL	1.1928 mL	2.3856 mL	11.9281 mL
20 mM	0.1193 mL	0.5964 mL	1.1928 mL	5.9640 mL
50 mM	0.0477 mL	0.2386 mL	0.4771 mL	2.3856 mL
100 mM	0.0239 mL	0.1193 mL	0.2386 mL	1.1928 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc