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Phenyltoloxamine
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Catalog No. T60391Cas No. 92-12-6
Phenyltoloxamine (Bistrimin) is an antihistamine with sedative and analgesic properties, and it exhibits strong Sigma-1 receptor binding affinity with a Ki of 160 nM [1] [2] [3].
Phenyltoloxamine
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Catalog No. T60391Cas No. 92-12-6
Phenyltoloxamine (Bistrimin) is an antihistamine with sedative and analgesic properties, and it exhibits strong Sigma-1 receptor binding affinity with a Ki of 160 nM [1] [2] [3].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Phenyltoloxamine (Bistrimin) is an antihistamine with sedative and analgesic properties, and it exhibits strong Sigma-1 receptor binding affinity with a Ki of 160 nM [1] [2] [3]. |
| Targets&IC50 | Sigma 1 Receptor:160 nM (Ki) |
| In vitro | Phenyltoloxamine, within a concentration range of 10-50 μM over 24 hours, demonstrates cytotoxic effects on EVSA-T cells [2]. Additionally, it exhibits significant binding affinity for the Sigma 1 Receptor (S1R), with a K i value of 160 nM [3]. At a higher concentration of 100 μM, Phenyltoloxamine inhibits the CYP2D6 enzyme in human liver by 99.0% [4]. |
| Molecular Weight | 255.35 |
| Formula | C17H21NO |
| Cas No. | 92-12-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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