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KDM4-IN-4

🥰Excellent
Catalog No. T60354Cas No. 2230475-63-3

KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It inhibits H3K4Me3 binding to the Tudor domain in cellular contexts with an EC50 value of 105 μM, holding potential for anticancer research applications [1].

KDM4-IN-4

KDM4-IN-4

🥰Excellent
Purity: 99.61%
Catalog No. T60354Cas No. 2230475-63-3
KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It inhibits H3K4Me3 binding to the Tudor domain in cellular contexts with an EC50 value of 105 μM, holding potential for anticancer research applications [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$293In StockIn Stock
5 mg$722In StockIn Stock
10 mg$987In StockIn Stock
25 mg$1,520In StockIn Stock
50 mg$1,980In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.61%
ee:98.38%
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COA CSFC HNMR HPLC ORP

Product Introduction

Bioactivity
Description
KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It inhibits H3K4Me3 binding to the Tudor domain in cellular contexts with an EC50 value of 105 μM, holding potential for anticancer research applications [1].
Targets&IC50
KDM4A-Tudor domain:80 μM (Ki)
Chemical Properties
Molecular Weight245.36
FormulaC16H23NO
Cas No.2230475-63-3
SmilesO[C@@H]1[C@]2(C[C@@]([C@@H]1CN(C)C)(CC2)[H])C3=CC=CC=C3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 83.3 mg/mL (339.5 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.0756 mL20.3782 mL40.7564 mL203.7822 mL
5 mM0.8151 mL4.0756 mL8.1513 mL40.7564 mL
10 mM0.4076 mL2.0378 mL4.0756 mL20.3782 mL
20 mM0.2038 mL1.0189 mL2.0378 mL10.1891 mL
50 mM0.0815 mL0.4076 mL0.8151 mL4.0756 mL
100 mM0.0408 mL0.2038 mL0.4076 mL2.0378 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KDM4HistoneDemethylaseHistone Demethylase
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